COPI: mechanisms and transport roles

  • Victor W. Hsu
  • Jia- Shu Yang
  • Stella Y. Lee


Coat protein I (COPI) is considered one of the best characterized coat complexes, which represent the core machinery by which vesicle formation and cargo sorting are coupled to initiate vesicular transport (Bonifacino and Lippincott-Schwartz 2003; McMahon and Mills 2004). Our understanding of the molecular mechanisms by which COPI acts and the transport path- ways in which it operates has evolved significantly over the years, and with considerable accompanying controversy. These aspects of COPI research will be reviewed. See also Fig. 1 for a timeline that summarizes its key discoveries.


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Copyright information

© Springer-Verlag/Wien 2008

Authors and Affiliations

  • Victor W. Hsu
    • 1
  • Jia- Shu Yang
    • 2
    • 3
  • Stella Y. Lee
    • 2
  1. 1.Harvard Medical School Brigham and Women’s HospitalBostonUSA
  2. 2.Division of Rheumatology, Immunology and AllergyBrigham and Women’s HospitalBostonUSA
  3. 3.Department of MedicineHarvard Medical SchoolBostonUSA

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