Cerebral Vasospasm pp 297-302 | Cite as
Ecdysterone attenuates vasospasm following experimental subarachnoid haemorrhage in rabbits
Abstract
Cerebral vasospasm (CVS) remains a severe complication after subarachnoid haemorrhage (SAH), and there are not adequate medical treatments for it. Our previous study showed that ecdysterone might prevent CVS following SAH in vitro. To observe the effects of ecdysterone on CVS in vivo, changes of neurological function, cerebral angiogram and morphological changes of basilar arteries were observed, and the effects of ecdysterone on rabbits were compared with those of nimodipine. The number of rabbits with high scores of food intake and neurological deficit in SAH/ecdysterone group reduced compared with SAH group. The average diameter of basilar arteries deceased by 23%, 20% and 14% in SAH, SAH/nimodipine and SAH/ecdysterone group, respectively, when compared with baseline. There were several structural changes of the basilar artery in the SAH group, including endothelial impairment, emergence of inflammatory cells and smooth muscle cells disarrangement. These changes were alleviated with nimodipine or ecdysterone treatment. We conclude that ecdysterone can alleviate neural function deficits, attenuate vasospasm and protect vessel structure after SAH.
Keywords
Subarachnoid haemorrhage ecdysterone nimodipine rabbit animal modelPreview
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