Multiple Endocrine Neoplasia Type 2B

  • Electron Kebebew
  • Jessica E. Gosnell
  • Emily Reiff


Multiple endocrine neoplasia type 2 (MEN 2) is a distinct hereditary syndrome that has an autosomal pattern of inheritance (OMIM 2005). There have been 500-1000 MEN 2 kindreds reported in the literature. The MEN 2 syndrome consists of three variants: MEN 2A, MEN 2B and familial medullary thyroid cancer (Table 1). Patients with MEN 2B develop medullary thyroid cancer (100%), pheochromocytoma, mucocutaneous neuromas and have characteristic physical features. MEN 2B accounts for 5–10% of MEN 2 cases. In patients with MEN 2B, neuromas may involve the skin, musculoskeletal system, gastrointestinal tract and eyes (Schimke et al. 1968, Williams and Pollock 1966a).


Thyroid Cancer Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia Type Medullary Thyroid Medullary Thyroid Cancer 
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© Springer-Verlag/Wien 2008

Authors and Affiliations

  • Electron Kebebew
    • 1
  • Jessica E. Gosnell
    • 1
  • Emily Reiff
    • 1
  1. 1.Department of Surgery and UCSF Comprehensive Cancer CenterUniversity of CaliforniaSan FranciscoUSA

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