Advertisement

Silver Hair Syndromes: Chediak-Higashi Syndrome (CHS) and Griscelli Syndromes (GS)

  • Marimar Saez-De-Ocariz
  • Luz Orozco-Covarrubias
  • Carola Duràn-McKinster
  • Ramòn Ruiz-Maldonado

Abstract

Normal pigmentation is a complex biological process and in the human, at least 127 different genes have been identified (Bennett and Lamoreaux 2003). Colour loci are the genetic loci in which mutations can affect pigmentation of the hair, skin, and/or eyes.

Keywords

Accelerate Phase Hair Shaft Natural Killer Cell Function Haemophagocytic Syndrome Griscelli Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bennett DC, Lamoreaux ML (2003) The colour loci of mice-a genetic century. Pigment Cell Res 16: 333–344.PubMedCrossRefGoogle Scholar
  2. Lambert J, Onderwater J, Vander Haeghen Y, Vancoillie G, Koerten HK, Mommaas AM, Naeyaert JM (1998) Myosins V-colocalized with melanosomes and subcortical actin bundles not associated with stress fibers in human epidermal melanocytes. J Invest Dermatol 111: 835–840.PubMedCrossRefGoogle Scholar

References

  1. Apitz-Castro R, Cruz MR, Ledezma E, Merino F, Ramirez-Duque P, Dangelmeier C, Holmsen H (1985) The storage pool deficiency in platelets from humans with the Chediak-Higashi syndrome: study of six patients. Br J Haematol 59: 471–483.PubMedCrossRefGoogle Scholar
  2. Aslan Y, Erduran E, Gedik Y, Mocan H, Yildiran A (1996) The role of high dose methylprednisolone and splenectomy in the accelerated phase of Chediak-Higashi syndrome. Acta Haematol 96: 105–107.PubMedCrossRefGoogle Scholar
  3. Ballard R, Tien RD, Nohria V, Juel V (1994) The Chediak-Higashi syndrome: CT and MRI findings. Pediatr Radiol 24: 266.PubMedCrossRefGoogle Scholar
  4. Barak Y, Nir E (1987) Chediak-Higashi syndrome. Am J Pediatr Hematol Oncol 9: 42–55.PubMedCrossRefGoogle Scholar
  5. Barbosa MDFS, Nguyen QA, Tchernev VT, Ashley JA, Detter JC, Blaydes SM, Brandt SJ, Chotai D, Hodgman C, Solari RC, Lovett M, Kingsmore SF (1996) Identification of the homologous beige and Chediak-Higashi syndrome. Nature 382: 262–265.PubMedCrossRefGoogle Scholar
  6. Barbosa MDFS, Barrat FJ, Tchernev VT, Nguyen QA, Mishra VS, Colman SD, Pastural E, Dufourq-Lagelouse R, Fisher A, Holcombe RF, Wallace MR, Brandt SJ, de Saint Basile G, Kingsmore SF (1997) Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse. Hum Molec Genet 6: 1091–1098.PubMedCrossRefGoogle Scholar
  7. Barrat FJ, Auloge L, Pastural E, Lagelous RD, Vilmer E, Cant AJ, Weissenbach J, Le Paslier D, Fischer A, de Saint Basile G (1996) Genetic and physical mapping of the Chediak-Higashi syndrome on chromosome 1q42-43. Am J Hum Genet 59: 625–632.PubMedGoogle Scholar
  8. Beguez-Cesar A (1943) Neutropenia crónica maligna familiar con granulaciones atípicas de los leucocitos. Bol Soc Cubana Pediatr 15: 900–922Google Scholar
  9. Buchanan GR, Handin RI (1976) Platelet function in the Chediak-Higashi syndrome. Blood 47: 941–948.PubMedGoogle Scholar
  10. Chediak MM (1952) Nouvelle anomalie leucocytaire de caractere constitutionnel et familial. Rev Hematol 7: 362–367.PubMedGoogle Scholar
  11. De Freitas GR, de Oliveira CP, Reis RS, Sarmento MR, Gaspar NK, Fialho M, Praxedes H (1999) Seizures in Chediak-Higashi syndrome. Arq Neuropsiquiatr 57: 495–497.PubMedGoogle Scholar
  12. Farah RA, Rogers R (2004) Chediak-Higashi syndrome. In: Roach ES, Allen VS (eds.) Neurocutaneous Disorders. New York: Cambridge University Press, pp. 296–300.Google Scholar
  13. Fukai K, Oh J, Karim MA, Moore KJ, Kandil HH, Ito H, Burger J, Spritz RA (1996) Homozygosity mapping of the gene for Chediak-Higashi syndrome to chromosome 1q42-44 in a segment of conserved synteny that includes the mouse beige locus (bg). Am J Hum Genet 59: 620–624.PubMedGoogle Scholar
  14. Fukuda M, Morimoto T, Ishida Y, Suzuki Y, Murakami Y, Kida K, Ohnishi A (2003) Improvement of peripheral neuropathy with oral prednisone in Chediak-Higashi syndrome. Eur J Pediatr 31: 87–90.Google Scholar
  15. Gallin JL, Klinerman JA, Padgett GA, Wolff SM (1975) Defective mononuclear leukocyte chemotaxis in the Chediak-Higashi syndrome of humans, mink and cattle. Blood 45: 863–870.PubMedGoogle Scholar
  16. Haddad E, Le Diest F, Blanche S, Benkerrou M, Rohrlich P, Vilmer E, Griscelli C, Fischer A (1995) Treatment of Chediak-Higashi syndrome by allogeneic bone marrow transplantation: report of 10 cases. Blood 85: 3328–3333.PubMedGoogle Scholar
  17. Hauser RA, Friedlander J, Baker MJ, Thomas J, Zuckerman KS (2000) Adult Chediak-Higashi parkinsonian syndrome with dystonia. Mov Disord 15: 705–708.PubMedCrossRefGoogle Scholar
  18. Higashi O (1954) Congenital gigantism of peroxidase granules: the first case ever reported of qualitative abnormality of peroxidase. Tokai J Exp Clin Med 59: 315–332.Google Scholar
  19. Jacobi C, Koerner C, Fruehauf S, Rottenburger C, Storch-Hagenlocher B, Grau AJ (2005) Presynaptic dopaminergic pathology in Chediak-Higashi syndrome with parkinsonian syndrome. Neurology 24: 1814–1815.CrossRefGoogle Scholar
  20. Kahraman MM, Prieur DJ (1990) Chediak-Higashi syndrome in the cat: prenatal diagnosis by evaluation of amniotic fluid cells. Am J Med Genet 36: 321–327.PubMedCrossRefGoogle Scholar
  21. Karim MA, Suzuki K, Fukai K, Oh J, Nagle D, Moore KJ, Barbosa E, Falik-Borenstein T, Filipovich A, Ishida Y, Kivrikko S, Klein C, Kreuz F, Levin A, Miyajima H, Regueiro J, Russo C, Uyama E, Vierimaa O, Spritz RA (2002) Apparent genotype-phenotype correlation in childhood, adolescent, and adult Chediak-Higashi syndrome. Am J Med Genet 108: 16–22.PubMedCrossRefGoogle Scholar
  22. Kinugawa N (1990) Epstein-Barr virus infection in Chediak-Higashi syndrome mimicking acute lymphocytic leukemia. Am J Pediatr Hematol Oncol 12: 182–186.PubMedCrossRefGoogle Scholar
  23. Kjeldsen L, Calafat J, Borregaard N (1998) Giant granules of neutrophils in Chediak-Higashi syndrome are derived from azurophil granules but not from specific and gelatinase granules. J Leukoc Biol 64: 72–77.PubMedGoogle Scholar
  24. Kunieda T, Ide H, Nakagiri M, Yoneda K, Konfortov B, Ogawa H (2000) Localization of the locus responsible for Chediak-Higashi in cattle to bovine chromosome 28. Anim Genet 31: 87–90.PubMedCrossRefGoogle Scholar
  25. Lockman LA, Kennedy WR, White JG (1967) The Chediak-Higashi syndrome electrophysiological and electron microscopic observations on the peripheral neuropathy. J Pediatr 70: 924–951.Google Scholar
  26. Malech HL, Nauseef WM (1997) Primary inherited defects in neutrophil function: etiology and treatment. Semin Hematol 34: 279–290.PubMedGoogle Scholar
  27. Merino E, Klein GO, Henle W, Ramirez-Duque P, Forsgren M, Amesty C (1983) Elevated antibody titers to Epstein-Barr virus and low natural killer cell activity in patients with Chediak-Higashi syndrome. Clin Ummunol Immunopathol 27: 326–339.CrossRefGoogle Scholar
  28. Misra VP, King RH, Harding AE, Muddle JR, Thomas PK (1991) Peripheral neuropathy in the Chediak-Higashi syndrome. Acta Neuropathol (Berl) 81: 354–358.CrossRefGoogle Scholar
  29. Mottonen M, Lanning M, Baumann P, Saarinen-Pihkala UM (2003) Chediak-Higashi syndrome: four cases from Northern Finland. Acta Pediatr 92: 1047–1051.CrossRefGoogle Scholar
  30. Nagle DL, Karim MA, Woolf EA, Holmgren L, Bork P, Misumi DJ, McGrail SH, Dussault BJ Jr, Perou CM, Boissy RE, Duyk GM, Spritz RA, Moore KJ (1996) Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. Nat Genet 14: 307–311.PubMedCrossRefGoogle Scholar
  31. Nowicki R, Szarmach H (2006) Chediak-Higashi syndrome. E-medicine from webMD: http://emedicine. com/derm/topic704.htmGoogle Scholar
  32. Padgett GA, Leader RW, Gorham JR, O’Mary CC (1964) The familial occurrence of Chediak-Higashi syndrome in mink and cattle. Genetics 49: 505–512.PubMedGoogle Scholar
  33. Patay Z (2005) Metabolic disorders. In: Tortori-Donati P (ed.) Pediatric Neuroradiology. Brain. Berlin: Springer, pp. 543–721.Google Scholar
  34. Perou CM, Moore KJ, Nagle DL, Misumi DJ, Woolf EA, McGrail SH, Holmgren L, Brody TH, Dussault BJ Jr, Monroe CA, Duyk GM, Pryor RJ, Li L, Justice MJ, Kaplan J (1996a) Identification of the murine beige gene by YAC complementation and positional cloning. Nature Genet 13: 303–308.PubMedCrossRefGoogle Scholar
  35. Perou CM, Justice MJ, Pryor RJ, Kaplan J (1996b) Complementation of the beige mutation in cultured cells by episomally replicating murine yeast chromosomes. Proc Nat Acad Sci USA 93: 5905–5909.PubMedCrossRefGoogle Scholar
  36. Pettit RE, Berdal KG (1984) Chediak-Higashi syndrome. Neurologic appearance. Arch Neurol 41: 1001–1002.PubMedGoogle Scholar
  37. Roder JC, Haliotis T, Laing L, Kozbor D, Rubin P, Pross H, Boxer LA, White JG, Fauci AS, Mostowski H, Matheson DS (1982) Further studies of natural killer cell function in Chediak-Higashi patients. Immunology 46: 555–560.PubMedGoogle Scholar
  38. Root RK, Rosenthal AS, Balestra DJ (1972) Abnormal bacterial, metabolic and lysosomal function of Chdeiak-Higashi syndrome leukocytes. J Clin Invest 51: 649–665.PubMedCrossRefGoogle Scholar
  39. Rubin CM, Burke BA, McKenna RW, McClain KL, White JG, Nesbit ME Jr, Filipovich AH (1985) The accelerated phase of Chediak-Higashi syndrome. An expression of the virus associated haemophagocytic syndrome? Cancer 56: 524–530.PubMedCrossRefGoogle Scholar
  40. Sayanagi K, Fujikado T, Onodera T, Tano Y (2003) Chediak-Higashi syndrome with progressive visual loss. Jpn J Ophthalmol 47: 304–306.PubMedCrossRefGoogle Scholar
  41. Sheramata W, Kott SK, Cyr DP (1974) The Chediak-Higashi-Steinbrinck syndrome. Presentation of three cases with features resembling spinocerebellar degeneration. Arch Neurol 25: 289–294.Google Scholar
  42. Silveira-Moriyama L, Moriyama TS, Gabbi TV, Ranvaud R, Barbosa ER (2004) Chediak-Higashi syndrome with parkinsonism. Mov Disord 19: 472–475.PubMedCrossRefGoogle Scholar
  43. Spritz RA (1998) Genetic defects in Chediak-Higashi syndrome and the beige mouse. J Clin Immunol 18: 97–105.PubMedCrossRefGoogle Scholar
  44. Stato A (1955) Chediak and Higashi’s disease. Probable identity of “new leukocytal anomaly (Chediak) ” and “congenital gigantism of peroxidase granules (Higashi) ”. Tohoku J Exp Med 61: 201–210.CrossRefGoogle Scholar
  45. Steinbrinck W (1948) Uber eine neue Granulationsanomalie der Leurkocyten. Dtsch Arch Klin Med 193: 577–581.Google Scholar
  46. Taiby H (1996) Chediak-higashi syndrome. In: Taiby H, Lachman RS (eds.) Radiology of Syndromes, Metabolic Disorders, and Skeletal Dysplasia. St-Louis: Mosby, pp. 81–82.Google Scholar
  47. Tardieu M, Lacroix C, Neven B, Bordigoni P, de Saint Basile G, Blanche S, Fisher A (2005) Progressive neurologic dysfunctions 20 years after allogeneic bone marrow transplantation for Chediak-Higashi syndrome. Blood 106: 40–42.PubMedCrossRefGoogle Scholar
  48. Uyama E, Hirano T, Yoshida A, Doi O, Maruoka S, Araki S (1991) An adult case of Chediak-Higashi syndrome with parkinsonism and marked atrophy of the central nervous system. Rinsho Shinkeigaku 31: 24–31.PubMedGoogle Scholar
  49. Uyama E, Hirano T, Ito K, Nakashima H, Sugimoto M, Naito M, Uchino M, Ando M (1994) Adult Chediak-Higashi syndrome presenting as parkinsonism and dementia. Acta Neurol Scand 89: 175–183.PubMedCrossRefGoogle Scholar
  50. Van Hale P (1987) Chediak-Higashi syndrome. In: Gomez MR (ed.) Neurocutaneous Diseases. A Practical Approach. Boston: Butterworths, pp. 209–213.Google Scholar
  51. Windhorst DB, Padgett G (1973) The Chediak-Higashi syndrome and the homologous trait in animals. J Invest Dermatol 60: 529–537.PubMedCrossRefGoogle Scholar
  52. Zhao H, Boissy YL, Abdel-Malek Z, King RA, Nordlund JJ, Boissy RE (1994) On the analysis of the pathophysiology of Chediak-Higashi syndrome. Defects expressed by cultured melanocytes. Lab Invest 71: 25–34.PubMedGoogle Scholar

References

  1. Aksu G, Kutekculer N, Genel F, Vergin C, Omowaire B (2003) Griscelli syndrome without hemophagocytosis in an eleven-year-old girl: expanding the phenotypic spectrum of Rab27A mutations in humans. Am J Med Genet A 116: 329–333.CrossRefGoogle Scholar
  2. Anikster Y, Huizing M, Anderson PD, Fitzpatrick DL, Klar A, Gross-Kieselstein E, Berkun Y, Shazberg G, Gahl WA, Hurvitz H (2002) Evidence that Griscelli syndrome with neurological involvement is caused by mutations in Rab27A, not Myo5a. Am J Hum Genet 71: 407–414.PubMedCrossRefGoogle Scholar
  3. Arico M, Zecca M, Santoro N, Caselli D, Maccario R, Danesino C, de Saint Basile G, Locatelli F (2002) Successful treatment of Griscelli syndrome with unrelated donor allogenic hematopoietic stem cell transplantation. Bone Marrow Transplant 29: 995–998.PubMedCrossRefGoogle Scholar
  4. Bahadoran P, Ballotti R, Ortonne JP (2003a) hypomelanosis, immunity, central nervous system: no more “and”, not the end. Am J Med Genet 116A: 334–337.PubMedCrossRefGoogle Scholar
  5. Bahadoran P, Ortonne JP, Ballotti R, de Saint-Basile G (2003b) Comment on Elejalde syndrome and relationship with Griscelli syndrome. Am J Med Genet 166A: 408–409.CrossRefGoogle Scholar
  6. De Saint Basile G, Fisher A (2001) The role of cytotoxicity in lymphocyte homeostasis. Curr Opin Immunol 13: 549–554.PubMedCrossRefGoogle Scholar
  7. Duran-McKinster C, Rodríguez-Jurado R, Ridaura C, Orozco-Covarrubias ML, Tamayo L, Ruiz-Maldonado R (1999) Elejalde syndrome — A melanolysosomal neurocutaneous syndrome. Clinical and Morphological findings in 7 patients. Arch Dermatol 135: 182–186.PubMedCrossRefGoogle Scholar
  8. Elejalde BR, Valencia A, Gilbert EF, Marin G, Molina J, Holguin J (1977) Neuro-ectodermal melanolysosomal disease: an autosomal recessive pigment mutation in man. Am J Hum Genet 29: 39A (abstract).Google Scholar
  9. Elejalde BR, Holguin J, Valencia A, Gilbert EF, Molina J, Marin G, Arango LA (1979) Mutations affecting pigmentation in man: I. Neuroectodermal melanosomal disease. Am J Med Genet 3: 65–80.PubMedCrossRefGoogle Scholar
  10. Fukuda M (2005) Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families. J Biochem 137: 9–16.PubMedCrossRefGoogle Scholar
  11. Griscelli C, Durandy A, Guy-Grand D, Daguillard F, Herzog C, Pruneiras M (1978) A syndrome associating partial albinism and immunodeficiency. Am J Med 65: 691–702.PubMedCrossRefGoogle Scholar
  12. Huizing M, Anikster Y, Gahl WA (2002) Reply to Menasche et al. Am J Hum Genet 71: 1238.CrossRefGoogle Scholar
  13. Hume AN, Collinson LM, Hopkins CR, Strom M, Burral DC, Bossi G, Griffiths GM, Seabra MC (2002) The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes. Traffic 3: 193–202.PubMedCrossRefGoogle Scholar
  14. Ivanovich J, Mallory S, Storer T, Ciske D, Ciske D, Hing A (2001) 12-year-old male with Elejalde syndrome (neuroectodermal melanolysosomal disease). Am J Med Genet 98: 313–316.PubMedCrossRefGoogle Scholar
  15. Libby RT, Lillo C, Kitamoto J, Williams DS, Steel KP (2004) Myosin Va is required for normal photoreceptor synaptic activity. J Cell Sci 117: 4509–4515.PubMedCrossRefGoogle Scholar
  16. Mamishi S, Modarressi MH, Pourakbari B, Tamizifar B, Mahjoub F, Fahimzad A, Alyasin S, Bemanian MH, Hamidiyeh AA, Fazlollahi MR, Ashrafi MR, Isaeian A, Khotaei G, Yeganeh M, Parvaneh N (2008) Analysis of RAB27A Gene in Griscelli Syndrome type 2: Novel Mutations Including a Deletion Hotspot. J Clin Immunol Mar 19 [Epub ahead of print].Google Scholar
  17. Mancini AJ, Chan LS, Paller AS (1998) Partial albinism with immunodeficiency: Griscelli syndrome. Report of a case and review of the literature. J Am Acad Dermatol 38: 295–300.PubMedCrossRefGoogle Scholar
  18. Manglani M, Adhvaryu K, Seth B (2004) Griscelli syndrome — a case report. Indian Pediatr 41: 734–737.PubMedGoogle Scholar
  19. Marks MS, Seabra MC (2001) The melanosome: membrane dynamics in black and white. Nat Rev Mol Cell Biol 2: 738–748.PubMedCrossRefGoogle Scholar
  20. Menasche G, Pastural E, Feldman J, Certain S, Ersoy F, Dupuis S, Wulfraat N, Bianci D, Fisher A, Le Deist F, de Saint Basile G (2000) Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome. Nat Genet 25: 173–176.PubMedCrossRefGoogle Scholar
  21. Menasche G, Fisher A, de Saint Basile G (2002) Griscelli syndrome types 1 and 2. Am J Hum Genet 71: 1237–1238.PubMedCrossRefGoogle Scholar
  22. Menasche G, Ho Ch, Sanal O, Feldmann J, Tezcan I, Ersoy F, Houdusse A, Fischer A, de Saint Basile G (2003) Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1). J Clin Invest 112: 450–456.PubMedGoogle Scholar
  23. Neeft M, Wieffer M, de Jong AS, Negroiu G, Metz CH, van Loon A, Griffith J, Krijgsveld J, Wulffraat N, Koch H, Heck AJ, Brose N, Kleijmeer M, van der Sluijs P (2005) Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells. Mol Biol Cell 16: 731–741.PubMedCrossRefGoogle Scholar
  24. OMIMTM (2006) Online Mendelian Inheritance in Men. Baltimore: Johns Hopkins University Press, http:// www.ncbi.nlm.nih.gov/omimGoogle Scholar
  25. Pastural E, Barrat JF, Dufourcq-Lagelouse R, Certain S, Sanal O, Jabado N, Sager R, Griscelli C, Fisher A, de Saint Basile G (1997) Griscelli disease maps to chromosome 15q21 and is associated to mutations in myosin Va. Nat Genet 116: 289–292.CrossRefGoogle Scholar
  26. Pastural E, Ersoy F, Yalamn N, Wulffrat N, Grillo E, Ozkinay F, Tezcan I, Gedikoglu G, Philippe N, Fisher A, de Saint Basile G (2000) Two genes are responsible for Griscelli syndrome at the same 15q21 locus. Genomics 63: 299–306.PubMedCrossRefGoogle Scholar
  27. Provance DW, James TL, Mercer JA (2002) Melanophilinn, the product of the leaden locus is required for targeting of myosin-Va to melanosomes.Traffic 3: 124–132.PubMedCrossRefGoogle Scholar
  28. Rath S, Jain V, Marwaha RK, Trehan A, Rajesh LS, Kumar V (2004) Griscelli syndrome. Indian J Pediatr 71: 173–175.PubMedCrossRefGoogle Scholar
  29. Seabra MC, Mules EH, Hume AN (2002) Rab GTPase, intracellular traffic and disease. Trends Mil Med 8: 23–30.CrossRefGoogle Scholar
  30. Sanal O, Yel L, Kucukali T, Gilbert-Barnes E, Tardieu M, Texcan I, Ersoy F, Metin A, de Saint Basile G (2000) An allelic variant of Griscelli disease: presentation with severe hypotonia, mental-motor retardation, and hypopigmentation consistent with Elejalde syndrome (neuroectodermal melanolysosomal disorder). J Neurol 247: 570–572.PubMedCrossRefGoogle Scholar
  31. Scheinfeld NS (2003) Syndromic albinism: a review of genetics and phenotypes. Dermatol Online 9: 5–14.Google Scholar
  32. Scheinfeld NS, Johnson AM (2006) Griscelli syndrome. Emedicine from webMD. http://www.emedicine.com/ derm/topic926.htmGoogle Scholar
  33. Westbroek W, Tuchman M, Tinloy B, De Wever O, Vilboux T, Hertz JM, Hasle H, Heilmann C, Helip-Wooley A, Kleta R, Gahl WA (2008) A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome. Mol Genet Metab Apr 6 [Epub ahead of print].Google Scholar
  34. Wilson SM, Yip R, Swing DA, O’Sullivan TN, Zhang Y, Novak EK, Swank RT, Russel LB, Copeland NG, Jenkins NA (2000) A mutation in Rab27a causes the vesicle transport defects observed in ashen mice. Proc Nat Acad Sci 97: 7933–7938.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 2008

Authors and Affiliations

  • Marimar Saez-De-Ocariz
    • 1
  • Luz Orozco-Covarrubias
    • 1
  • Carola Duràn-McKinster
    • 1
  • Ramòn Ruiz-Maldonado
    • 1
  1. 1.Department of DermatologyNational Institute of PaediatricsMexico CityMexico

Personalised recommendations