Lungenmetastasen

  • B. Rau
  • D. Kandioler
  • G. Stamatis
Chapter

Auszug

Sekundäre Neoplasien der Lunge finden sich im Obduktionsgut von Tumorpatienten in 20 % bis 55 % (Lee, 1983). Hämatogene Lungenmetastasen werden häufig beim Melanom, Osteochondrosarkom, Hypernephrom, Tumoren im Kopf-/Halsbereich als auch beim Rektumkarzinom gefunden. Bei gastrointestinalen Tumoren ist die Lunge meistens das sekundäre Metastasierungsorgan nach der Leber. Allerdings besteht auch bei gastrointestinalen Karzinomen häufig eine lymphogene Tumorzellverschleppung in die Lunge, insbesondere dann, wenn es sich um einen lokal fortgeschrittenen Primärtumor handelt. So findet man eine diffuse Tumorausbreitung im Lymphsystem der Lunge, die Lymphangiosis carcinomatosa, am häufigsten bei primären Karzinomen von Magen, Pankreas, Mamma, Prostata und Ovarien.

This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Antunes M, Bernardo J, Salete M, Prieto D, Eugenio L, Tavares P (1999) Excision of pulmonary metastases of osteogenic sarcoma of the limbs. Cardio-Thoracic Surgery 15: 592–596CrossRefGoogle Scholar
  2. Baaklini WA, Reinoso MA, Gorin AB, Sharafkaneh A, Manian P (2000) Diagnostic yield of fiberoptic bronchoscopy in evaluating solitary pulmonary nodules. Chest 117: 1049–1054PubMedCrossRefGoogle Scholar
  3. Bacci G, Briccoli A, Ferrari S, Saeter G, Donati D, Longhi A et al. (2000) Neoadjuvant chemotherapy for osteosarcoma of the extremities with synchronous lung metastases: treatment with cisplatin, adriamycin and high dose of methotrexate and ifosfamide. Oncol Rep 7(2): 339–346PubMedGoogle Scholar
  4. Bacci G, Bertoni F, Longhi A, Ferrari S, Forni C, Biagini R et al. (2003) Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity. Histologic response to preoperative chemotherapy correlates with histologic subtype of the tumor. Chirurg 97(12): 3068–3075Google Scholar
  5. Billingsley KG, Burt ME, Jara E, Ginsberg RJ, Woodruff JM, Leung DH et al. (1999) Pulmonary metastases from soft tissue sarcoma: analysis of patterns of diseases and postmetastasis survival. Ann Surg 229(5): 602–610PubMedCrossRefGoogle Scholar
  6. Briccoli A, Ferrari S, Picci P, Mercuri M, Bacci G, Guernelli N (1999) Surgical treatment of lung metastases from osteosarcoma, based on a series of 206 operated cases. Ann Chir 53: 207–214PubMedGoogle Scholar
  7. Couraud L, Laurent F, Velly JF, Dorcier J, Zanotti L, Martigne C et al. (1990) Contribution of x-ray computed tomography and MRI to the surgical diagnosis of bronchial cancers. Comparative evaluation of x-ray computed tomography, MRI and thoracotomy in 111 cases. Ann Chir 44: 649–654PubMedGoogle Scholar
  8. De Giacomo T, Rendina EA, Venuta F, Ciccone AM, Coloni GF (1999) Thoracoscopic resection of solitary lung metastases from colorectal cancer is a viable therapeutic option. Chest 115: 1441–1443PubMedCrossRefGoogle Scholar
  9. Friedel G, Pastorino U, Ginsberg RJ, Goldstraw P, Johnston M, Pass H et al. (2002) Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases. Eur J Cardiothorac Surg 22(3): 335–344PubMedCrossRefGoogle Scholar
  10. Girard P, Ducreux M, Baldeyrou P, Rougier P, Le Chevalier T, Bourgaran J et al. (1996) Surgery for lung metastases from colorectal cancer: Analysis of prognostic factors. J Clin Oncol 14: 2047–2053PubMedGoogle Scholar
  11. Iizasa T, Suzuki M, Yoshida S, Motohashi S, Yasufuku K, Iyoda A et al. (2006) Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer. Ann Thorac Surg 82(1): 254–260PubMedCrossRefGoogle Scholar
  12. Jin GY, Lee JM, Lee YC, Han YM (2004) Acute cerebral infarction after radiofrequency ablation of an atypical carcinoid pulmonary tumor. Am J Roentgenol 182(4): 990–992Google Scholar
  13. Kandioler D, Kroemer E, Tuechler H, End A, Mueller MR, Wolner E et al. (1998) Long-term results after repeated surgical removal of pulmonary metastases. Ann Thorac Surg 65: 909–912PubMedCrossRefGoogle Scholar
  14. Khan JH, McElhinney J, Rahman S, George TI, Clark OH, Merrick SH (1998) Pulmonary metastases of endocrine origin. Chest 114: 526–534PubMedCrossRefGoogle Scholar
  15. Kolodziejski L, Goralczyk J, Dyczek S, Duda K, Nabialek T (1999) The role of surgery in lung metastases. Eur J Surg Oncol 25: 410–417CrossRefGoogle Scholar
  16. Landreneau RJ, Mack MJ, Hazelrigg SR, Naunheim KS, Keenan RJ, Ferson PF (1995) The role of video-assisted thoracic surgery in thoracic oncological practice [see comments]. Cancer Invest 13: 526–539PubMedCrossRefGoogle Scholar
  17. Laurent F, Latrabe V, Vergier B, Montaudon M, Dubrez J (2000) CT-guided transthoracic needle biopsy of pulmonary nodules smaller than 20 mm: results with an automated 20-gauge coaxial cutting needle. Clin Radiol 55: 281–287PubMedCrossRefGoogle Scholar
  18. Lee Y (1983) Breast carcinoma:pattern of metastases at autopsy. J Surg Oncol 23: 175–180PubMedCrossRefGoogle Scholar
  19. Lin JC, Wiechmann RJ, Szwerc MF, Hazelrigg SR, Ferson PF, Naunheim K et al. (1999) Diagnostic and therapeutic video-assisted thoracic surgery resection of pulmonary metastases. Surgery 126: 636–642PubMedGoogle Scholar
  20. Loehe F, Kobinger S, Hatz RA, Helmberger T, Loehrs U, Fuerst H (2001) Value of systematic mediastinal lymph node dissection during pulmonary metastasectomy. Ann Thorac Surg 72(1): 225–229PubMedCrossRefGoogle Scholar
  21. Lucas JD, O’Doherty MJ, Wong JC, Bingham JB, McKee PH, Fletcher CD et al. (1998) Evaluation of fluorodeoxyglucose positron emission tomography in the management of soft-tissue sarcomas. J Bone Joint Surg Br 80(3): 441–447PubMedCrossRefGoogle Scholar
  22. McCormack P, Burt M, Bains M, Martini N, Rusch VW, Ginsberg R (1992) Lung resection for colorectal metastases. Arch Surg 127: 1403–1406PubMedGoogle Scholar
  23. Milne EN (1976) Pulmonary metastases: vascular supply and diagnosis. Int J Radiat Oncol Biol Phys 1 (7–8): 739–742PubMedGoogle Scholar
  24. Mineo TC, Ambrogi V, Mineo D, Pompeo E (2001) Transxiphoid hand-assisted videothoracoscopic surgery. Ann Thorac Surg 83(6): 1978–1984CrossRefGoogle Scholar
  25. Mutsaerts E, Zoetmulder FA, Meijer S, Baas P, Hart AA, Rutgers EJ (2001) Outcome of thoracoscopic pulmonary metastasectomy evaluated by confirmatory thoracotomy. Ann Thorac Surg 72: 230–233PubMedCrossRefGoogle Scholar
  26. Nagakura S, Shirai Y, Yamato Y, Yokoyama N, Suda T, Hatakeyama K (2001) Simultaneous detection of colorectal carcinoma liver and lung metastases does not warrant resection. J Am Coll Surg 193: 153–160PubMedCrossRefGoogle Scholar
  27. Parsons AM, Detterbeck FC, Parker LA (2004) Accuracy of helical CT in the detection of pulmonary metastases: is intraoperative palpation still necessary? Ann Thorac Surg 78(6): 1910–1916PubMedCrossRefGoogle Scholar
  28. Pastorino U (2002) History of the surgical management of pulmonary metastases and development of the International Registry. Semin Thorac Cardiovasc Surg 14(1): 18–28PubMedCrossRefGoogle Scholar
  29. Pastorino U, Buyse M, Friedel G, Ginsberg R, Girard P, Goldstraw P et al. (1997) Long-term results of lung metastasectomy: Prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg 113: 37–49CrossRefGoogle Scholar
  30. Pinsky P, Freedman M, Oken M, Kvale P, Caporaso N, Gohagan J (2007) Prevalence of non-cancer-related abnormalities on low-dose spiral computer tomography versus chest radiograph in a screening population. Thorax 62(2): 190PubMedCrossRefGoogle Scholar
  31. Rau B, Hunerbein M, Below C, Schlag PM (1998) Video-assisted thoracic surgery. Staging and management of thoracic tumors. Surg Endosc 12: 133–136PubMedCrossRefGoogle Scholar
  32. Remy-Jardin J, Remy-Jardin M, Giraud F (1993) Pulmonary nodules: Detection with thick section spiral CT versus conventional CT. Radiology 187: 513–520PubMedGoogle Scholar
  33. Robinson BJ, Rice TW, Strong SA, Rybicki LA, Blackstone EH (1999) Is resection of pulmonary and hepatic metastases warranted in patients with colorectal cancer? J Thorac Cardiovasc Surg 117: 66–76PubMedCrossRefGoogle Scholar
  34. Rolle A, Pereszlenyi A, Koch R, Richard M, Baier B (2006) Is surgery for multiple lung metastases reasonable? A total of 328 consecutive patients with multiple-laser metastasectomies with a new 1318-nm Nd:YAG laser. J Thorac Cardiovasc Surg 131(6): 1236–1242PubMedCrossRefGoogle Scholar
  35. Rosso F, Smirne C, Papalla E, Rena O, Ruffini E, Oliaro A (1998) Surgical treatment of lung metastases. Minerva Chir 54: 495–500Google Scholar
  36. Schirren J, Wassenberg D, Krysa S, Branscheid D, diRienzo G, Drings P et al. (1994) Metastasis surgery of the lung — Indications, results, and prognostic factors in the interdisciplinary concept. Pneumologie 48: 469–474PubMedGoogle Scholar
  37. Schirren J, Krysa S, Bülzebruck H, Zweibarth A, Schneider P, Drings P et al. (1995) Results of surgical treatment of pulmonary metastases from soft tissue sarcomas. Recent Results Cancer Res 138: 123–138PubMedGoogle Scholar
  38. Steinke K, Glenn D, King J, Clark W, Zhao J, Clingan P et al. (2004) Percutaneous imaging-guided radiofrequency ablation in patients with colorectal pulmonary metastases: 1-year follow-up. Ann Surg Oncol 11(2): 207–212PubMedCrossRefGoogle Scholar
  39. Suh R, Reckamp K, Zeidler M, Cameron R (2005) Radiofrequency ablation in lung cancer: promising results in safety and efficacy. Oncology (Williston Park) 19 (11 Suppl 4): 12–21Google Scholar
  40. Vaughn C, Mychaskiw G, Sewell P (2002) Massive hemorrhage during radiofrequency ablation of a pulmonary neoplasm. Anesth Analg 94(5): 1149–1151PubMedCrossRefGoogle Scholar
  41. Virgo KS, Naunheim KS, Johnson FE (2006) Preoperative workup and postoperative surveillance for patients undergoing pulmonary metastasectomy. Thorac Surg Clin 16(2): 125–131, v.PubMedCrossRefGoogle Scholar
  42. Vogl TJ, Wetter A, Lindemayr S, Zangos S (2005) Treatment of unresectable lung metastases with transpulmonary chemoembolization: preliminary experience. Radiology 234(3): 917–922PubMedCrossRefGoogle Scholar
  43. Watanabe M, Deguchi H, Sato M, Ozeki Y, Tanaka S, Izumi Y et al. (1998) Midterm results of thoracoscopic surgery for pulmonary metastases especially from colorectal cancers. J Laparoend & Adv Surg Techn 8: 195–200CrossRefGoogle Scholar
  44. Welter S, Jakobs J, Krbek T, Poettgen C, Stamatis G (2007) Prognostic impact of lymph node involvement in pulmonary metastasis from colorectal cancer. Eur J Cardiothorac Surg 31(2): 167–172PubMedCrossRefGoogle Scholar
  45. Zanella A, Marchet A, Mainente P, Nitti D, Lise M (1997) Resection of pulmonary metastases from colorectal carcinoma. Eur J Surg Oncol 23: 424–427PubMedCrossRefGoogle Scholar
  46. Zollinger A, Hofer CK, Pasch T (2001) Preoperative pulmonary evaluation: facts and myths. Curr Opin in Anaesthesiol 14: 59–63CrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 2008

Authors and Affiliations

  • B. Rau
    • 1
  • D. Kandioler
    • 2
  • G. Stamatis
    • 3
  1. 1.Klinik für Chirurgie und Chirurgische OnkologieCharité, Campus BuchBerlinDeutschland
  2. 2.Allgemein- Thorax- und Gefäßchirurgie Universitätsklinik für ChirurgieMedizinische Universität Wien, Allgemeines KrankenhausWienÖsterreich
  3. 3.Chefarzt Thoraxchirurgie und thorakale EndoskopieRuhrlandklinik Essen-HeidhausenEssenDeutschland

Personalised recommendations