Pathophysiology of dystonia

  • M. Hallett
Conference paper

DOI: 10.1007/978-3-211-45295-0_72

Part of the Journal of Neural Transmission. Supplementa book series (NEURALTRANS, volume 70)
Cite this paper as:
Hallett M. (2006) Pathophysiology of dystonia. In: Riederer P., Reichmann H., Youdim M.B.H., Gerlach M. (eds) Parkinson’s Disease and Related Disorders. Journal of Neural Transmission. Supplementa, vol 70. Springer, Vienna


Understanding of the pathophysiology of dystonia derives primarily from studies of focal dystonias. Physiological investigations have revealed a number of abnormalities that may reflect the genetic substrate that predisposes certain individuals to develop dystonia. There is a loss of inhibition in the central nervous system, and a loss of surround inhibition specifically. Plasticity is increased, and there are sensory abnormalities. Which of these disorders is primary is uncertain.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • M. Hallett
    • 1
  1. 1.Human Motor Control SectionNINDS, NIHBethesdaUSA

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