Parkinson’s Disease and Related Disorders pp 485-488
Pathophysiology of dystonia
- Cite this paper as:
- Hallett M. (2006) Pathophysiology of dystonia. In: Riederer P., Reichmann H., Youdim M.B.H., Gerlach M. (eds) Parkinson’s Disease and Related Disorders. Journal of Neural Transmission. Supplementa, vol 70. Springer, Vienna
Understanding of the pathophysiology of dystonia derives primarily from studies of focal dystonias. Physiological investigations have revealed a number of abnormalities that may reflect the genetic substrate that predisposes certain individuals to develop dystonia. There is a loss of inhibition in the central nervous system, and a loss of surround inhibition specifically. Plasticity is increased, and there are sensory abnormalities. Which of these disorders is primary is uncertain.
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