Multiple system atrophy and autonomic failure

  • C. J. Mathias
Part of the Journal of Neural Transmission. Supplementa book series (NEURALTRANS, volume 70)


Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that affects adults. It is characterised by autonomic failure affecting many systems; cardiovascular, urinary, sexual, gastrointestinal and sudomotor, amongst others. In addition there are motor deficits, resulting in both parkinsonian and/or cerebellar features. This review will outline the clinical features, investigations and management of MSA, with a particular emphasis on autonomic failure.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • C. J. Mathias
    • 1
    • 2
    • 3
  1. 1.Neurovascular Medicine Unit, Faculty of MedicineImperial College London at St. Mary’s HospitalLondonUK
  2. 2.Autonomic UnitNational Hospital for Neurology & Neurosurgery, Queen SquareLondonUK
  3. 3.Institute of NeurologyUniversity College LondonLondonUK

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