Proposed animal model of severe Parkinson’s disease: neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum

  • R. M. Kostrzewa
  • J. P. Kostrzewa
  • R. Brus
  • R. A. Kostrzewa
  • P. Nowak
Part of the Journal of Neural Transmission. Supplementa book series (NEURALTRANS, volume 70)

Summary

Rats lesioned shortly after birth with 6-hydroxydopamine are posed as a near-ideal model of severe Parkinson’s disease, because of the non-lethality of the procedure, near-total destruction of nigrostriatal dopaminergic fibers, near-total dopamine (DA)-denervation of striatum, reproducibility of effect, and relative absence of overt behavioral effects – there is no aphasia, no adipsia, and no change in motor activity. In vivo microdialysis findings reinforce the utility of the animal model, clearly demonstrating L-DOPA beneficial actions without an increase in hydroxyl radical production.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • R. M. Kostrzewa
    • 1
  • J. P. Kostrzewa
    • 1
  • R. Brus
    • 2
  • R. A. Kostrzewa
    • 1
  • P. Nowak
    • 2
  1. 1.Department of Pharmacology, Quillen College of MedicineEast Tennessee State UniversityJohnson CityUSA
  2. 2.Department of PharmacologyMedical University of SilesiaZabrzePoland

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