Potential sources of increased iron in the substantia nigra of parkinsonian patients

  • M. Gerlach
  • K. L. Double
  • M. B. H. Youdim
  • P. Riederer
Part of the Journal of Neural Transmission. Supplementa book series (NEURALTRANS, volume 70)

Summary

Histopathological, biochemical and in vivo brain imaging techniques, such as magnetic resonance imaging and transcranial sonography, revealed a consistent increase of substantia nigra (SN) iron in Parkinson’s disease (PD). Increased iron deposits in the SN may have genetic and non-genetic causes. There are several rare movement disorders associated with neurodegeneration, and genetic abnormalities in iron regulation resulting in iron deposition in the brain. Non-genetic causes of increased SN iron may be the result of a disturbed or open blood-brain-barrier, local changes in the normal iron-regulatory systems, intraneuronal transportation of iron from iron-rich area into the SN and release of iron from intracellular iron storage molecules. Major iron stores are ferritin and haemosiderin in glial cells as well as neuromelanin in neurons. Age- and disease dependent overload of iron storage proteins may result in iron release upon reduction. Consequently, the low molecular weight chelatable iron complexes may trigger redox reactions leading to damage of biomolecules. Additionally, upon neurodegeneration there is strong microglial activation which can be another source of high iron concentrations in the brain.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • M. Gerlach
    • 1
  • K. L. Double
    • 2
  • M. B. H. Youdim
    • 3
  • P. Riederer
    • 4
  1. 1.Laboratory for Clinical Neurochemistry, Department of Child and Adolescence Psychiatry and PsychotherapyUniversity of WürzburgWürzburgGermany
  2. 2.Prince of Wales Medical Research InstituteSydneyAustralia
  3. 3.Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, and Department of PharmacologyTechnion-Faculty of MedicineHaifaIsrael
  4. 4.Laboratory for Clinical Neurochemistry, Department of Psychiatry and Psychotherapy, and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases ResearchUniversity of WürzburgGermany

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