Stromal—epithelial interaction in type IV collagenase expression and activation: The role in cancer metastasis

  • Y. E. Shi
  • Y. Liu
Chapter
Part of the Experientia Supplementum book series (EXS, volume 74)

Abstract

It is the process of metastasis in cancer which impairs the ability of surgery to cure all but its earliest stages. In histologic observations of carcinomas, it is generally noted that as epithelial growth becomes dysregulated, the stromal-epithelial tissue compartmentalization also can become disturbed. The dissolution of the epithelial basement membrane signals local invasion of the disease; blood vessel infiltration (angiogenesis) is thought to allow the tumor cells to spread via lymphatic and hematogenous means to nearby and to distant organs. Metastasis is thought to depend upon alterations in cell adhesion, motility, proteolysis, and the ability to survive in another organ’s environments.

Keywords

Breast Cancer Basement Membrane Cancer Metastasis Human Breast Cancer Cell Line Interstitial Collagenase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Birkhäuser Verlag 1995

Authors and Affiliations

  • Y. E. Shi
    • 1
  • Y. Liu
    • 2
  1. 1.Department of Pediatrics and Pathology, Long Island Jewish Medical CenterAlbert Einstein College of MedicineNew Hyde ParkUSA
  2. 2.Department of Pediatrics, Long Island Jewish Medical CenterAlbert Einstein College of MedicineNew Hyde ParkUSA

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