Summary
Dynorphin A (1–10) was radioiodinated directly via electrophilic substitution of the reactive tyrosine. The uptake of this labelled dynorphin in glioma cell cultures was measured. Tracer uptake was compared with the non-specific tumour tracer T1-201. TI-201 showed a time independent uptake over the whole incubation time of 4 hours. In contrast, increasing accumulation of radioactivity was found with I-125 labelled dynorphin. The increasing uptake over time may be evidence for a specific binding process with a possible potential for receptor imaging in man.
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© 1996 Birkhäuser Verlag Basel/Switzerland
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Wolf, H. et al. (1996). Uptake of I-125 radiolabelled dynorphin in glioma cell cultures. In: Krisch, B., Mentlein, R. (eds) The Peptidergic Neuron. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9010-6_37
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DOI: https://doi.org/10.1007/978-3-0348-9010-6_37
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-9866-9
Online ISBN: 978-3-0348-9010-6
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