GABA: Receptors, Transporters and Metabolism pp 321-324 | Cite as
Pharmacological Studies on Generalized Absence Seizure Regulation in Genetic and Drug-Induced Models
Summary
Pharmacological profiles of generalized absence seizures in animal models were studied. Selective GABAB antagonists, CGP 35348 and CGP 46381, suppressed absence seizure behavior and spike and wave discharges (SWDs) in lethargic (lh/lh) mice and γ-butyrolactone (GBL)-treated mice (the γ-hydroxybutyric acid model: the GHB model) but not in stargazer (stg/stg) mice. Ethosuximide attenuated SWDs in all models used. In the GHB model, CGP 35348 is more potent than ethosuximide. These results suggest that GABAB receptors play a significant role in generalized absence seizures in lethargic and GHB model mice, whereas different mechanism is involved in those in stargazer mice.
Keywords
GABAB Receptor Absence Seizure Wave Discharge Burst Firing GABAs AntagonistPreview
Unable to display preview. Download preview PDF.
References
- 1.Snead OC III. Pharmacological models of generalized absence seizures in rodents. J Neural Transm 1992; 35: 7–19.Google Scholar
- 2.Hosford DA, Clark S, Cao Z, Wilson WA, Lin F-H, Morrisett RA and Huin A. The role of GABAB receptor activation in absence seizures of lethargic (lh/lh)mice. Science 1992; 257: 398–401.PubMedCrossRefGoogle Scholar
- 3.Qiao X and Noebels JL. Developmental analysis of hippocampal mossy fiber outgrowth in a mutant mouse with inherited spike-wave seizures. J Neurosci 1993; 13: 4622–4635.PubMedGoogle Scholar
- 4.Liu Z, Vergnes M, Depaulis A and Marescaux C. Involvement of intrathalamic GABAB neurotransmission in the control of absence seizures in the rats. Neuroscience 1992; 48: 8793.CrossRefGoogle Scholar
- 5.Striade M and Llinas R. The functional states of the thalamus and the associated neuronal interplay. Physiol Rev 1988; 68: 649–742.Google Scholar
- 6.Coulter DA, Hugeuenard JR and Prince DA. Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol 1989; 25: 582–593.PubMedCrossRefGoogle Scholar
- 7.Marescaux C, Liu Z, Bernasconi R and Vergnes M. GABAB receptors are involved in the occurrence of absence seizures in rats. Pharmacol Commun 1992; 2: 57–62.Google Scholar