Assessment of surfactant function

  • B. Robertson
  • S. Schürch
Chapter

Abstract

The film of surface active material (“surfactant”) that coats the terminal airspaces and conducting airways is of vital physiological importance. It prevents end-expiratory alveolar collapse by reducing the contractile force of surface tension at low lung volumes, and furthermore constitutes a barrier involved in the pulmonary defence system. Lung surfactant has a crucial role in the process of neonatal adaptation by lowering the alveolar opening pressure. It also stabilizes the newly aerated alveoli during the first ventilatory cycles, allowing effective gas exchange soon after birth. Inadequate supply of surfactant material in the lungs of a premature newborn baby is characteristically associated with a type of respiratory failure known as respiratory distress syndrome (RDS), a major cause of neonatal morbidity and mortality [1].

Keywords

Surface Tension Test Fluid Pulmonary Surfactant Transpulmonary Pressure Surfactant Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Basel AG 1998

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  • B. Robertson
  • S. Schürch

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