Gene Therapy

  • Joanne T. Douglas
  • David T. Curiel
Part of the Respiratory Pharmacology and Pharmacotherapy book series (RPP)


Gene therapy was originally conceived as an approach to the treatment of classic monogenic inherited disorders for which it was proposed that transfer of a normal copy of a single defective gene would revert the disease phenotype. However, as the field has evolved, it has been recognized that gene transfer is a rational option for the treatment of both acquired diseases, such as. cancer, and infectious diseases, such as AIDS, which have defined genetic components. In addition, the elucidation of the molecular basis of the host defense mechanisms against viral or bacterial pathogens suggests that these pathways could be exploited for therapeutic purposes using gene transfer technology. Therefore, gene therapy is now broadly defined as the transfer of genetic material to the cells of an individual for therapeutic purposes.


Cystic Fibrosis Gene Therapy Idiopathic Pulmonary Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Adenoviral Vector 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Basel AG 1999

Authors and Affiliations

  • Joanne T. Douglas
    • 1
  • David T. Curiel
    • 1
  1. 1.Division of Pulmonary and Critical Care Medicine, Department of Medicine and Gene Therapy ProgramUniversity of Alabama at BirminghamBirminghamUSA

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