Abstract
The aim of the present study was to compare, in preclinical models, the therapeutic efficacy of radioimmunotherapy in colorectal cancer to equitoxic chemotherapy, as well as to evaluate, in a pilot clinical trial, their efficacy in small volume disease. The data suggest that radioimmunotherapy may be a viable therapeutic option in colorectal cancer patients with limited disease. Myelotoxicity is the only dose-limiting organ toxicity. Although most patients were treated below the maximum tolerated dose, encouraging anti-tumor effects have been observed.
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© 1999 Springer Basel AG
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Behr, T.M. et al. (1999). Radioimmunotherapy of Colorectal Cancer in Small Volume Disease: Preclinical Evaluation in Comparison to Equitoxic Chemotherapy and Preliminary Results of an Ongoing Phase-I/II Clinical Trial. In: Bergmann, H., Köhn, H., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research XXIII. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8782-3_7
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DOI: https://doi.org/10.1007/978-3-0348-8782-3_7
Publisher Name: Birkhäuser, Basel
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