Recent advances in immunosuppressants

  • Bijoy Kundu
  • Sanjay K. Khare
Chapter
Part of the Progress in Drug Research book series (PDR, volume 52)

Summary

In recent years, a large number of structurally diverse immunosuppressants have been discovered that are effective for the treatment of organ transplantation. Some of them are undergoing clinical trials and may soon enter into routine clinical practice. These compounds are either chemical entities obtained from natural sources/synthetic means or biomaterials such as monoclonal antibodies/gene products/proteins. They have been found to interfere at different stages of T cell activation and proliferation, and can be identified as inhibitors of nucleotide synthesis, growth factor signal transduction and differentiation. Newer strategies involving combination of new agents with traditional immunosuppressants, monoclonal antibodies and gene therapy offer enormous potential, not only for the investigation of mechanisms pertaining to graft rejection, but also for its therapeutic prevention.

Keywords

Immunosuppressants graft rejection Oligopeptides monoclonal antibodies triple drug regimen gene therapy 

Glossary of abbreviations

CTL

Dcytotoxic T lymphocytes

CsA

cyclosporin A

GVHD

graft versus host disease

PHA

phytohemagglutinin

DHODH

dihydroorotate dehydrogenase

HPLC

high performance liquid chromatography

PKM

pokweed mitogen

MLR

mixed lymphocyte reaction

DSG

15, deoxyspergualin

MHC

major histocompatibility complex

IFN

interferon

moab

monoclonal antibodies

rHu

recombinant human

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Copyright information

© Springer Basel AG 1999

Authors and Affiliations

  • Bijoy Kundu
    • 1
  • Sanjay K. Khare
    • 1
  1. 1.Division of BiopolymersCentral Drug Research InstituteLucknowIndia

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