Neutrophils

  • Moira Whyte
Chapter
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Neutrophils are the rapid response cells of acute inflammation and a major component of host defence. Their ability to ingest bacteria and other microbes was recognised by Elie Metchnikoff in the 19th century, but in recent years the double-edged nature of the inflammatory response has been recognised. Despite their beneficial role in host defence, neutrophils and their pro-inflammatory products are increasingly implicated in the pathogenesis of acute and chronic inflammatory diseases. In the lung these include chronic bronchitis and emphysema, asthma, respiratory distress syndrome, bronchiectasis and a number of interstitial lung diseases. Thus, understanding the pro-inflammatory host defence functions of the neutrophil, and the mechanisms by which these are terminated, may yield insights into the pathogenesis of diseases which are a major cause of morbidity and mortality in the developed world.

Keywords

NADPH Oxidase Idiopathic Pulmonary Fibrosis Human Neutrophil Neutrophil Elastase Neutrophil Apoptosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Basel AG 2000

Authors and Affiliations

  • Moira Whyte
    • 1
  1. 1.Respiratory Medicine, Division of Molecular and Genetic MedicineRoyal Hallamshire HospitalSheffieldUK

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