Atopic dermatitis

  • Carla A. F. M. Bruilrizeel-Koomen
Chapter
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Atopic dermatitis (AD) is part of the atopy syndrome. It is the most common allergic skin disease. In this chapter the clinical characteristics and pathogenesis will be discussed. Therapy will be discussed in a separate chapter.

Keywords

Atopic Dermatitis Allergic Rhinitis Food Allergen Atopic Disease Atopic Dermatitis Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Hanifin F, Rajka G (1980) Diagnostic features of atopic dermatitis. Acta Dermatol Venereol (Stockh) 92: 44–47Google Scholar
  2. 2.
    Schultz-Larsen F (1986) A genetic epidemiologic study in a population based twin sam-ple. J Am Acad Dermatol 15: 487–494CrossRefGoogle Scholar
  3. 3.
    Diepgen TL, Fartasch M (1993) Recent epidemiologic and genetic studies in atopic der-matitis. Acta Dermatol Venereol (Stockh) 176: 13–21Google Scholar
  4. 4.
    Sandford AJ, Shirikawa T, Moffatt F et al (1993) Localization of atopy and beta sub-unit of high affinity IgE receptor on chromosome 11q. Lancet 241: 332–334CrossRefGoogle Scholar
  5. 5.
    Savin JA (1993) Atopy and its inheritance: genetics is building a bridge between the immediate and delayed type components of atopy. Brit Med J 307: 1019–1020PubMedCrossRefGoogle Scholar
  6. 6.
    Coleman R, Trembath RC, Harper JJ et al (1993) Chromosome 11q13 and atopy under-lying atopic eczema. Lancet 341: 1121–1122PubMedCrossRefGoogle Scholar
  7. 7.
    Foelster-Holst R, Moises HW, Yang L et al (1998) Linkage between atopy and the IgE high affinity receptor gene at 11q13 in atopic dermatitis families. Hum Genet 102: 236–239PubMedCrossRefGoogle Scholar
  8. 8.
    Cox HE, Moffatt MF, Faux JA et al (1998) Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin IgE receptor. Br J Dermatol 138: 182–187PubMedCrossRefGoogle Scholar
  9. 9.
    Bieber T, de la Salle H, Wollenberg A et al (1992) Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin IgE. J Exp Med 175: 1285–1290PubMedCrossRefGoogle Scholar
  10. 10.
    Wang B, Rieger A, Kilgus O et al (1992) Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc-epsilon R1. J Exp Med 175: 1353–1365PubMedCrossRefGoogle Scholar
  11. 11.
    Schultz-Larsen F, Diepgen TL, Svensson A (1996) The occurrence of atopic dermatitis in North-Europe: an international questionnaire study. J Am Acad Dermatol 34: 760–764PubMedCrossRefGoogle Scholar
  12. 12.
    Rajka G (1989) Essential aspects of atopic dermatitis. Springer Verlag BerlinCrossRefGoogle Scholar
  13. 13.
    Bruijnzeel-Koomen CAFM, van Wichen DF, Toonstra J et al (1986) The presence of IgE molecules on epidermal Langerhans cells frm patients with atopic dermatitis. Arch Dermatol Res 278: 199–205CrossRefGoogle Scholar
  14. 14.
    Maurer D, Ebner C, Reiniger B et al (1996) The high affinity IgE receptor medaites IgE dependent allergen presentation. J Immunol 154: 6285–6290Google Scholar
  15. 15.
    Thepen T, Langeveld-Wildschut EG, Bihari IC et al (1996) Biphasic response against aeroallergens in atopic eczema showing a switch from an initial Th2 response to a Th1 response: an immunocytochemical study. J Allergy Clin Immunol 97: 823–827CrossRefGoogle Scholar
  16. 16.
    Grewe M, Walther S, Guyfko K et al (1995) Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients. J Invest Dermatol 105: 823–827CrossRefGoogle Scholar
  17. 17.
    Hamid Q, Boguniewicz M, Leung DYM (1994) Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J OM Invest 94: 870–876CrossRefGoogle Scholar
  18. 18.
    Tupker RA, de Monchy JGR, Coenraads PJ et al (1996) Induction of atopic dermatitis by inhalation of house dust mite. J Allergy Clin Immunol 97: 1069–1070CrossRefGoogle Scholar
  19. 19.
    Brinkman L, Aslander MA, Raaymakers JAM et al (1997) Bronchial and cutaneous responses in atopic dermatitis patients after allergen inhalation challenge. Clin Exp Allergy 27: 1043–1051PubMedCrossRefGoogle Scholar
  20. 20.
    Tan BB, Weald D, Strickland I et al (1996) Double blind controlled trial of effect of house dust mite allergen avoidance on atopic dermatitis. Lancet 347: 15–18PubMedCrossRefGoogle Scholar
  21. 21.
    Langeveld-Wildschut EG et al (1995) Evaluation of variables influencing the outcome of the atopy patch test. J Allergy Clin Immunol 96: 66–73PubMedCrossRefGoogle Scholar
  22. 22.
    Fabrizi G, Corbo GM, Ferrante E et al (1992) The relationship between allergy clinical symptoms and bronchial responsiveness in atopic dermatitis. Acta Dermatol Venereol (Stockh) 176: 68–73Google Scholar

Copyright information

© Springer Basel AG 2000

Authors and Affiliations

  • Carla A. F. M. Bruilrizeel-Koomen
    • 1
  1. 1.Department of DermatologyUniversity Hospital UtrechtUtrechtNetherlands

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