Retinoid treatment of photoaged skin

  • A. A. Bajoghli
  • B. A. Gilchrest
Part of the MCBU Molecular and Cell Biology Updates book series (MCBU)


Photoaging comprises the adverse effects of chronic ultraviolet radiation (UVR) on the skin, superimposed on the intrinsic aging process [1]. The magnitude of the problem of photoaging is large and expanding [2] as a result of factors such as increasing ultraviolet exposure from ozone layer depletion, increasing popularity of tanning salons, and “sun-worshipping” behavior of the public, combined with demographic shifts that have tripled the proportion of older persons in society during the past century and are projected again to double in the next century [3]. Ongoing public awareness of the consequences of chronic sun exposure has not yet diminished the population’s desire to tan or motivation to use adequate sun protection measures. Consequently, photoaging is a common reason for consulting dermatologists and other physicians, and the public interest in products intended to reverse its effects is enormous. This chapter reviews evidence gathered from human and animal studies regarding the ability of topical retinoid application to reverse many aspects of the photoaging process.


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Copyright information

© Springer Basel AG 2000

Authors and Affiliations

  • A. A. Bajoghli
    • 1
  • B. A. Gilchrest
    • 1
  1. 1.Department of DermatologyBoston University School of MedicineBostonUSA

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