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Thrombocytopenia in HIV, Idiopathic Thrombocytopenic Purpura (ITP), Vasculitis and Toxic Bone Marrow Injury: An Etiologic Entity ? Results of a Comparative Study

  • Th. Behr
  • W. Becker
  • H.-J. Bair
  • J. Schwab
  • F. Wolf
Part of the Advances in Pharmacological Sciences book series (APS)

Summary

34 patients with clinical symptomatology of disturbance in platelet turnover were investigated using In-111-labeled autologous platelets. Platelet kinetics were determined using mathematical algorithms. In HIV associated thrombocytopenia, a decreased platelet production was found together with a shortened survival of platelets. In ITP, the diminished survival was predominant, while in toxic bone marrow injury, the platelet production was compromised. Patients with vasculitis presented with enhanced platelet production.

Keywords

Idiopathic Thrombocytopenic Purpura Platelet Production Autologous Platelet Platelet Survival Peripheral Platelet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. (1).
    Kelton JG, Gibbons S. Autoimmune platelet destruction: idiopathic thrombocytopenic purpura. Semin Thromb Haemost 1982; 8: 83–104.CrossRefGoogle Scholar
  2. (2).
    Morris L, Distenfeld A, Amorosi E, Karpatkin S. Autoimmune thrombocytopenic purpura in homosexual men. Ann Int Med 1982; 96: 714–717.PubMedGoogle Scholar
  3. (3).
    Savona S, Nardi MA, Lennette ET, Karpatkin S. Thrombocytopenic purpura in narcotic addicts. Ann Int Med 1985; 102: 737–741.PubMedGoogle Scholar
  4. (4).
    Ratnoff OD, Menitove JE, Aster RH, Lederman MM. Coincident classic hemophilia and “idiopathic” thrombocytopenic purpura in patients under treatment with concentrates of antihemophilic factor (factor VIII). N Engl J Med 1983; 308: 439–442.PubMedCrossRefGoogle Scholar
  5. (5).
    Walsh CM, Nardi MA, Karpatkin S. On the mechanism of thrombocytopenic purpura in sexually active homosexual men. N Engl J Med 1984; 311: 635–639.PubMedCrossRefGoogle Scholar
  6. (6).
    Stricker RB, Abrams DI, Corash L, Shuman MA. Target platelet antigen in homosexual men with immune thrombocytopenia. N Engl J Med 1985; 313: 1375–1380.PubMedCrossRefGoogle Scholar
  7. (7).
    Ballern PJ, Belzberg A, Devine DV, Lyster D, Spruston B, Chambers H, Doubroff P, Mikulash K. Kinetik studies of the mechanism of thrombocytopenia in patients with human immunodeficiency virus infection. N Engl J Med 1992; 327: 1779–1784.CrossRefGoogle Scholar
  8. (8).
    Lamy T, Moisan A, Dauriac C, Ghandour C, Morice P, Le Prise PY. Splenectomy in idiopathic thrombocytopenic purpura: its correlation with the sequestration of autologous Indium-111-labeled platelets. J Nucl Med 1993; 34: 182–186.PubMedGoogle Scholar
  9. (9).
    Lotter MG, Heyns AP, Badenhorst PN, Wessels P, van Zyl JM, Kotze HF, Minnaar PC. Evaluation of mathematical models to assess platelet kinetics. J Nucl Med 1986; 27: 1192–1201.PubMedGoogle Scholar
  10. (10).
    Harker LA, Finch CA. Thrombokinetics in man. J Clin Invest 1969; 48: 963–974.PubMedCrossRefGoogle Scholar
  11. (11).
    Basch RS, Kouri YH, Karpatkin S. Expression of CD4 by human megakaryocytes. Proc Natl Acad Sci USA 1990; 87: 8085–8089.PubMedCrossRefGoogle Scholar
  12. (12).
    Zucker-Franklin D, Cao Y. Megakaryocyte of human immunodeficiency virus-infected individuals express viral RNA. Proc Natl Acad Sci USA 1989; 86: 5595–5599.PubMedCrossRefGoogle Scholar
  13. (13).
    Landonio G, Nosari A, Spinelli F. HIV related thrombocytopenia. N Engl J Med 1993; 328: 1785–1786.PubMedCrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag Basel 1995

Authors and Affiliations

  • Th. Behr
    • 1
    • 2
  • W. Becker
    • 1
    • 2
  • H.-J. Bair
    • 1
    • 2
  • J. Schwab
    • 1
    • 2
  • F. Wolf
    • 1
    • 2
  1. 1.Departments of Nuclear Medicine and Medicine IIIFriedrich-Alexander-University of Erlangen-NurembergErlangenGermany
  2. 2.Institute of Clinical RheumatologyFriedrich-Alexander-University of Erlangen-NurembergErlangenGermany

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