Thrombocytopenia in HIV, Idiopathic Thrombocytopenic Purpura (ITP), Vasculitis and Toxic Bone Marrow Injury: An Etiologic Entity ? Results of a Comparative Study
34 patients with clinical symptomatology of disturbance in platelet turnover were investigated using In-111-labeled autologous platelets. Platelet kinetics were determined using mathematical algorithms. In HIV associated thrombocytopenia, a decreased platelet production was found together with a shortened survival of platelets. In ITP, the diminished survival was predominant, while in toxic bone marrow injury, the platelet production was compromised. Patients with vasculitis presented with enhanced platelet production.
KeywordsIdiopathic Thrombocytopenic Purpura Platelet Production Autologous Platelet Platelet Survival Peripheral Platelet
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