Oxidative stress in neurobiology: An important role for iron

  • J. M. C. Gutteridge
Conference paper
Part of the Molecular and Cell Biology Updates book series (MCBU)

Summary

The brain has regions with a high iron content, and selective increases in iron occur in several neurological diseases. Low levels of intrinsic antioxidants and high levels of oxidisable substrate (polyunsaturated fatty acids) make the brain a vulnerable target for oxidative stress leading to molecular damage.

Keywords

Tartaric Acid Neuronal Ceroid Lipofuscinoses Gerbil Brain Fenton Chemistry Fenton Catalyst 
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Copyright information

© Birkhäuser Verlag Basel/Switzerland 1995

Authors and Affiliations

  • J. M. C. Gutteridge
    • 1
  1. 1.Oxygen Chemistry Laboratory Unit of Critical Care, Department of Anaesthesia and Intensive CareRoyal Brompton Hospital and National Heart and Lung InstituteLondonUK

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