Summary

Bacteria adhere to natural and synthetic, medically important surfaces within an extracellular polymer generically termed the glycocalyx. This quasi-structure is a biofilm. The enhanced antibiotic resistance of biofilm bacteria, relative to floating (planktonic) bacteria, encourages the establishment of chronic bacterial infections. Resistance mechanisms include the hinderance of antibiotic diffusion by the glycocalyx, the physiology of the bacteria and the environment conditions of the niche in which the biofilm resides.

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Copyright information

© Birkhäuser Verlag Basel 1991

Authors and Affiliations

  • Brian D. Hoyle
    • 1
  • J. William Costerton
    • 1
  1. 1.Biofilm Group, Department of Biological SciencesUniversity of CalgaryCalgaryCanada

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