Xylitol in dietetics and medicine
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The detection of L-xylulose in the urine of non-pentosuric humans [250–252], guinea-pigs  and rats  indicated that this ketopentose may be a normal metabolite in mammals. This idea was supported by the discovery of a very active enzyme system for the reduction of L-xylulose to xylitol . It was also found that D-xylulose 5-phosphate, rather than Dribulose 5-phosphate, is the ketopentose substrate of transketolase in the 6phosphogluconate pathway [254, 255]. Simultaneously, new mitochondrial enzymes linking metabolically the two enantiomorphic forms of xylulose were studied in guinea-pig liver .
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