Effectors of Thermogenesis pp 89-93

Part of the Experientia Supplementum book series (EXS, volume 32)

The Identification of the Component in the Inner Membrane of Brown Adipose Tissue Mitochondria Responsible for Regulating Energy Dissipation

  • David G. Nicholls
  • Vibeke S. M. Bernson
  • Gillian M. Heaton

Abstract

The proton conductance of the inner membrane of hamster brown adipose tissue mitochondria can be regulated in vitro by exogenous purine nucleotides, which “bind to a component on the outer face of the inner membrane. This unique mechanism has been proposed to represent the molecular site of non-shivering thermogenesis in this tissue. Using a photo-affinity analogue of ATP, we have identified the nucleotide binding component as a protein of 32,000 daltons.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer Basel AG 1978

Authors and Affiliations

  • David G. Nicholls
    • 1
  • Vibeke S. M. Bernson
    • 2
  • Gillian M. Heaton
    • 1
  1. 1.Departments of Psychiatry and Biochemical Medicine, Ninewells Medical SchoolDundee UniversityDundeeScotland, UK
  2. 2.Wennergrens InstitutStockholm UniversitetStockholmSweden

Personalised recommendations