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Matrix Metalloproteinases

  • Viola VargováEmail author
  • Marek Pytliak
  • Viola Mechírová
Chapter
Part of the Experientia Supplementum book series (EXS, volume 103)

Abstract

Remodeling of extracellular matrix is crucial for many physiological (cell migration, proliferation, growth, and development) and pathological (remodeling of heart, carcinogenesis, metastasis, etc.) events. Thus, the interaction between cells and extracellular matrix plays a key role in normal development and differentiation of organism and many pathological states as well. Changes in extracellular matrix are regulated by a system of proteolytic enzymes that are responsible for proteolysis of huge quantity of extracellular matrix components. Matrix metalloproteinases (MMPs) represent the main group of regulating proteases in ECM. Ability of matrix metalloproteinases to modify the structural integrity of tissues is essential for certain aspects of normal physiology and pathology. The ability to process molecules such as growth factors, receptors, adhesion molecules, other proteinases, and proteinase inhibitors makes MMPs potent controllers of physiological and pathological events in the cell microenvironment. Overactivation of MMPs has been implicated in numerous disease states.

Keywords

Matrix metalloproteinases Cardiovascular risk Hypertension Diabetes Oncogenesis Pulmonary hypertension 

Abbreviations

ACE

Angiotensin converting enzyme

ADAMs

A Disintegrin and Metalloproteinase

Apo

Apolipoprotein

ARB

Angiotensin receptor blocker

BALF

Bronchoalveolar lavage fluid

BNP

Brain natriuretic peptide

cGMP

Cyclic guanosine monophosphate

COPD

Chronic obstructive pulmonary disease

DOCA

Deoxycorticosterone acetate

ECM

Extracellular matrix

FGF

Fibroblast growth factor

FLSs

Fibroblast-like synoviocytes

HF

Heart failure

IPF

Idiopathic pulmonary fibrosis

LPS

Lipopolysaccharide

MCT

Monocrotaline

MMPIs

Inhibitors of matrix metalloproteinases

MMPs

Matrix metalloproteinases

PAH

Pulmonary arterial hypertension

PDGF

Platelet-derived growth factor

PGE

Prostaglandin E

PKG

Protein kinase G

PPARγ

Peroxisome proliferator-activated receptor gamma

RECK

Reversion-inducing-cysteine-rich protein with kazal motifs

SLE

Systemic lupus erythematosus

SSc

Systemic sclerosis

TGF-β

Transforming growth factor-beta

TIMPs

Tissue inhibitors of matrix metalloproteinases

TNF-α

Tumor necrosis factor alpha

VSMC

Vascular smooth muscle cells

WT

Wild type

ZBG

Zinc-binding group

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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Viola Vargová
    • 1
    Email author
  • Marek Pytliak
    • 2
  • Viola Mechírová
    • 3
  1. 1.3rd Internal Clinic, Faculty of MedicineUPJŠKošiceSlovakia
  2. 2.Department of Nursing, Faculty of MedicineUPJŠKošiceSlovakia
  3. 3.1st Internal Clinic, Medical FacultyUPJŠKošiceSlovakia

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