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Other 4-Methanolquinolines, Amyl Alcohols and Phentathrenes: Mefloquine, Lumefantrine and Halofantrine

  • Francois NostenEmail author
  • Penelope A. Phillips-Howard
  • Feiko O. ter Kuile
Chapter
Part of the Milestones in Drug Therapy book series (MDT)

Abstract

This chapter describes mefloquine, pyronaridine, halofantrine, piperaquine and lumefantrine under the broader title of the 4-methanolquinolines, amyl alcohols and phentathrenes. We provide a brief resume of each drug, in terms of their chemical properties, formulae, pharmacokinetics, clinical indications for use, and their efficacy and safety. Recognizing the limited number of antimalarials available, and in the developmental pipeline, attention is focussed on describing the history of each drug and how their indications have evolved as data on safety in human populations accumulates over time, and how patterns of use have changed with growing multiple drug resistance. Their combined use with the artemisinin derivatives is briefly described and readers are recommended to consult other chapters in this book which more fully describe such combinations.

Keywords

Amyl Alcohol Artemisinin Derivative Food Vacuole Malaria Chemoprophylaxis Pfmdr1 Copy Number 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Basel AG 2011

Authors and Affiliations

  • Francois Nosten
    • 1
    • 2
    • 3
    Email author
  • Penelope A. Phillips-Howard
    • 4
  • Feiko O. ter Kuile
    • 5
  1. 1.Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, Churchill HospitalUniversity of OxfordOxfordUK
  2. 2.Shoklo Malaria Research UnitMae SotThailand
  3. 3.Mahidol UniversityBangkokThailand
  4. 4.Centre for Public HealthLiverpool John Moores UniversityLiverpoolUK
  5. 5.Malaria Epidemiology Unit Child and Reproductive Health GroupLiverpool School of Tropical MedicineLiverpoolUK

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