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International Conference on Computational Science

ICCS 2021: Computational Science – ICCS 2021 pp 670–683Cite as

Two-Way Coupling Between 1D Blood Flow and 3D Tissue Perfusion Models

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Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 12744))

Abstract

Accurately predicting brain tissue perfusion and infarct volume after an acute ischaemic stroke requires the two-way coupling of perfusion models on multiple scales. We present a method for such two-way coupling of a one-dimensional arterial blood flow model and a three-dimensional tissue perfusion model. The two-way coupling occurs through the pial surface, where the pressure drop between the models is captured using a coupling resistance. The two-way coupled model is used to simulate arterial blood flow and tissue perfusion during an acute ischaemic stroke. Infarct volume is estimated by setting a threshold on the perfusion change. By two-way coupling these two models, the effect of retrograde flow and its effect on tissue perfusion and infarct volume can be captured.

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Funding

This project (INSIST; www.insist-h2020.eu) has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 777072.

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Authors and Affiliations

  1. Computational Science Laboratory, Informatics Institute, Faculty of Science, University of Amsterdam, Science Park 904, Amsterdam, 1098, XH, The Netherlands

    Raymond M. Padmos, Gábor Závodszky & Alfons G. Hoekstra

  2. Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Parks Road, Oxford, OX1 3PJ, UK

    Tamás I. Józsa, Wahbi K. El-Bouri & Stephen J. Payne

  3. Liverpool Centre for Cardiovascular Science, Department of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool, UK

    Wahbi K. El-Bouri

Authors
  1. Raymond M. Padmos
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  2. Tamás I. Józsa
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  3. Wahbi K. El-Bouri
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  4. Gábor Závodszky
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  5. Stephen J. Payne
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  6. Alfons G. Hoekstra
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Corresponding author

Correspondence to Raymond M. Padmos .

Editor information

Editors and Affiliations

  1. AGH University of Science and Technology, Krakow, Poland

    Maciej Paszynski

  2. Ludwig-Maximilians-Universität München, Munich, Germany

    Dieter Kranzlmüller

  3. University of Amsterdam, Amsterdam, The Netherlands

    Valeria V. Krzhizhanovskaya

  4. University of Tennessee at Knoxville, Knoxville, TN, USA

    Jack J. Dongarra

  5. University of Amsterdam, Amsterdam, The Netherlands

    Peter M.A. Sloot

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Padmos, R.M., Józsa, T.I., El-Bouri, W.K., Závodszky, G., Payne, S.J., Hoekstra, A.G. (2021). Two-Way Coupling Between 1D Blood Flow and 3D Tissue Perfusion Models. In: Paszynski, M., Kranzlmüller, D., Krzhizhanovskaya, V.V., Dongarra, J.J., Sloot, P.M. (eds) Computational Science – ICCS 2021. ICCS 2021. Lecture Notes in Computer Science(), vol 12744. Springer, Cham. https://doi.org/10.1007/978-3-030-77967-2_56

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  • DOI: https://doi.org/10.1007/978-3-030-77967-2_56

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-77966-5

  • Online ISBN: 978-3-030-77967-2

  • eBook Packages: Computer ScienceComputer Science (R0)

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