Abstract
Accurately predicting brain tissue perfusion and infarct volume after an acute ischaemic stroke requires the two-way coupling of perfusion models on multiple scales. We present a method for such two-way coupling of a one-dimensional arterial blood flow model and a three-dimensional tissue perfusion model. The two-way coupling occurs through the pial surface, where the pressure drop between the models is captured using a coupling resistance. The two-way coupled model is used to simulate arterial blood flow and tissue perfusion during an acute ischaemic stroke. Infarct volume is estimated by setting a threshold on the perfusion change. By two-way coupling these two models, the effect of retrograde flow and its effect on tissue perfusion and infarct volume can be captured.
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This project (INSIST; www.insist-h2020.eu) has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 777072.
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Padmos, R.M., Józsa, T.I., El-Bouri, W.K., Závodszky, G., Payne, S.J., Hoekstra, A.G. (2021). Two-Way Coupling Between 1D Blood Flow and 3D Tissue Perfusion Models. In: Paszynski, M., Kranzlmüller, D., Krzhizhanovskaya, V.V., Dongarra, J.J., Sloot, P.M. (eds) Computational Science – ICCS 2021. ICCS 2021. Lecture Notes in Computer Science(), vol 12744. Springer, Cham. https://doi.org/10.1007/978-3-030-77967-2_56
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