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Mesoporous Silica Nanoparticles as Carriers for Biomolecules in Cancer Therapy

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Bio-Nanomedicine for Cancer Therapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1295))

Abstract

Mesoporous silica nanoparticles (MSNs) offer many advantageous properties for applications in the field of nanobiotechnology. Loading of small molecules into MSNs is straightforward and widely applied, but with the upswing of both research and commercial interest in biological drugs in recent years, also biomacromolecules have been loaded into MSNs for delivery purposes. MSNs possess many critical properties making them a promising and versatile carrier for biomacromolecular delivery. In this chapter, we review the effects of the various structural parameters of MSNs on the effective loading of biomacromolecular therapeutics, with focus on maintaining stability and drug delivery performance. We also emphasize recent studies involving the use of MSNs in the delivery of biomacromolecular drugs, especially for cancer treatment.

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Authors and Affiliations

  1. Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland

    Berrin Küçüktürkmen & Jessica M. Rosenholm

  2. Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Ankara, Turkey

    Berrin Küçüktürkmen

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  1. Berrin Küçüktürkmen
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Correspondence to Jessica M. Rosenholm .

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  1. Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

    Flavia Fontana

  2. Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

    Hélder A. Santos

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Küçüktürkmen, B., Rosenholm, J.M. (2021). Mesoporous Silica Nanoparticles as Carriers for Biomolecules in Cancer Therapy. In: Fontana, F., Santos, H.A. (eds) Bio-Nanomedicine for Cancer Therapy. Advances in Experimental Medicine and Biology, vol 1295. Springer, Cham. https://doi.org/10.1007/978-3-030-58174-9_5

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