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Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections

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Necrotizing Soft Tissue Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1294))

Abstract

In necrotizing soft tissue infection (NSTI) there is a need to identify biomarker sets that can be used for diagnosis and disease management. The INFECT study was designed to obtain such insights through the integration of patient data and results from different clinically relevant experimental models by use of systems biology approaches. This chapter describes the current state of biomarkers in NSTI and how biomarkers are categorized. We introduce the fundamentals of top-down systems biology approaches including analysis tools and we review the use of current methods and systems biology approaches to biomarker discover. Further, we discuss how different “omics” signatures (gene expression, protein, and metabolites) from NSTI patient samples can be used to identify key host and pathogen factors involved in the onset and development of infection, as well as exploring associations to disease outcomes.

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Acknowledgement

Financial support: The work was supported by the European Union Seventh Framework Programme: (FP7/2007-2013) under the grant agreement 305340 (INFECT project); the Swedish Governmental Agency for Innovation Systems (VINNOVA) under the frame of NordForsk (Project no. 90456, PerAID), and the Swedish Research Council and The Netherlands Organization for Health Research and Development (ZonMv) under the frame of ERA PerMed (Project 2018-151, PerMIT).

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Authors and Affiliations

  1. Laboratory of Systems and Synthetic Biology, Wageningen University and Research, Wageningen, The Netherlands

    Edoardo Saccenti

  2. Center for Infectious Medicine, Department of Medicine, ANA Futura, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden

    Mattias Svensson

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  1. Edoardo Saccenti
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Correspondence to Edoardo Saccenti .

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Editors and Affiliations

  1. Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Huddinge, Sweden

    Anna Norrby-Teglund

  2. Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Huddinge, Sweden

    Mattias Svensson

  3. Department of Clinical Science, University of Bergen, Bergen, Norway

    Steinar Skrede

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Saccenti, E., Svensson, M. (2020). Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections. In: Norrby-Teglund, A., Svensson, M., Skrede, S. (eds) Necrotizing Soft Tissue Infections. Advances in Experimental Medicine and Biology, vol 1294. Springer, Cham. https://doi.org/10.1007/978-3-030-57616-5_11

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