Abstract
The infections from viral pathogens pose a significant global health challenge. The emergence of viral strains resistant to conventional antiviruses and the adverse side effects due to their prolonged use slow down the application of many antiviral therapies. The silver nanoparticles are considered a potentially useful tool for preventing various pathogens. The silver nanoparticles have already proven its potential as an efficient antiviral agent offered by their unique physical and chemical properties. The silver nanoparticles provide an excellent opportunity for novel antiviral therapies as it can attack a broad range of viruses with a lower possibility for developing resistant antiviral strains compared to conventional antiviral drugs. This chapter discusses the application of silver nanoparticles as an efficient antiviral agent against human immunodeficiency virus, respiratory syncytial virus, hepatitis B virus, monkeypox virus. Furthermore, the effect of silver nanoparticles against coronaviruses and the development of silver nanoparticles on their application as an effective antiviral therapeutic agent against pathogenic viruses have been discussed in this chapter.
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References
Aftab, S., Kurbanoglu, S., Ozcelikay, G., Bakirhan, N.K., Shah, A., Ozkan, S.A.: Carbon quantum dots co-catalyzed with multiwalled carbon nanotubes and silver nanoparticles modified nanosensor for the electrochemical assay of anti-HIV drug Rilpivirine. Sensor. Actuat. B Chem. 285, 571–583 (2019). https://doi.org/10.1016/j.snb.2019.01.094
Baram-Pinto, D., Shukla, S., Perkas, N., Gedanken, A., Sarid, R.: Inhibition of herpes simplex virus type 1 infection by silver nanoparticles capped with mercaptoethane sulfonate. Bioconjug. Chem. 20, 1497–1502 (2009). https://doi.org/10.1021/bc900215b
Chen, Y.N., Hsueh, Y.H., Hsieh, C. Te, Tzou, D.Y., Chang, P.L.: Antiviral activity of graphene–silver nanocomposites against non-enveloped and enveloped viruses. Int. J. Environ. Res. Public Health 13, 4–6 (2016). https://doi.org/10.3390/ijerph13040430
Du, T., Zhang, J., Li, C., Song, T., Li, P., Liu, J., Du, X., Wang, S.: Gold/Silver hybrid nanoparticles with enduring inhibition of coronavirus multiplication through multisite mechanisms. Bioconjug. Chem (2020). https://doi.org/10.1021/acs.bioconjchem.0c00506
Elechiguerra, J.L., Burt, J.L., Morones, J.R., Camacho-Bragado, A., Gao, X., Lara, H.H., Yacaman, M.J.: Interaction of silver nanoparticles with HIV-1. J. Nanobiotechnol. 3, 1–10 (2005). https://doi.org/10.1186/1477-3155-3-6
Galdiero, S., Falanga, A., Vitiello, M., Cantisani, M., Marra, V., Galdiero, M.: Silver nanoparticles as potential antiviral agents. Molecules 16, 8894–8918 (2011). https://doi.org/10.3390/molecules16108894
Jeremiah, S.S., Miyakawa, K., Morita, T., Yamaoka, Y.: Potent antiviral effect of silver nanoparticles on SARS-CoV-2. 533, 195–200 (2020). https://doi.org/10.1016/j.bbrc.2020.09.018
Kumar, S.D., Singaravelu, G., Ajithkumar, S., Murugan, K., Nicoletti, M., Benelli, G.: Mangrove-mediated green synthesis of silver nanoparticles with high HIV-1 reverse transcriptase inhibitory potential. J. Clust. Sci. 28, 359–367 (2017). https://doi.org/10.1007/s10876-016-1100-1
Lara, H.H., Ayala-Nuñez, N.V., Ixtepan-Turrent, L., Rodriguez-Padilla, C.: Mode of antiviral action of silver nanoparticles against HIV-1. J. Nanobiotechnol. 8, 1–10 (2010a). https://doi.org/10.1186/1477-3155-8-1
Lara, H.H., Ixtepan-Turrent, L., Garza-Treviño, E.N., Rodriguez-Padilla, C.: PVP-coated silver nanoparticles block the transmission of cell-free and cell-associated HIV-1 in human cervical culture. J. Nanobiotechnology 8, 1–11 (2010b). https://doi.org/10.1186/1477-3155-8-15
Li, Y., Lin, Z., Zhao, M., Guo, M., Xu, T., Wang, C., Xia, H., Zhu, B.: Reversal of H1N1 influenza virus-induced apoptosis by silver nanoparticles functionalized with amantadine. RSC Adv. 6, 89679–89686 (2016a). https://doi.org/10.1039/c6ra18493f
Li, Y., Lin, Z., Zhao, M., Xu, T., Wang, C., Hua, L., Wang, H., Xia, H., Zhu, B.: Silver nanoparticle based codelivery of oseltamivir to inhibit the activity of the H1N1 influenza virus through ROS-mediated signaling pathways. ACS Appl. Mater. Interfaces 8, 24385–24393 (2016b). https://doi.org/10.1021/acsami.6b06613
Lu, L., Sun, R.W., Chen, R., Hui, C., Ho, C., Luk, J.M., Lau, G.K.K.: Original article silver nanoparticles inhibit hepatitis B virus. Antivir. Ther. 13, 253–262 (2007)
Mohammed Fayaz, A., Ao, Z., Girilal, M., Chen, L., Xiao, X., Kalaichelvan, P.T., Yao, X.: Inactivation of microbial infectiousness by silver nanoparticles-coated condom: A new approach to inhibit HIV- and HSV-transmitted infection. Int. J. Nanomedicine 7, 5007–5018 (2012). https://doi.org/10.2147/IJN.S34973
Morris, D., Ansar, M., Speshock, J., Ivanciuc, T., Qu, Y., Casola, A., Garofalo, R.: Antiviral and immunomodulatory activity of silver nanoparticles in experimental rsv infection. Viruses 11, (2019). https://doi.org/10.3390/v11080732
Rai, M., Kon, K., Ingle, A., Duran, N., Galdiero, S., Galdiero, M.: Broad-spectrum bioactivities of silver nanoparticles: The emerging trends and future prospects. Appl. Microbiol. Biotechnol. 98, 1951–1961 (2014). https://doi.org/10.1007/s00253-013-5473-x
Rogers, J.V., Parkinson, C.V., Choi, Y.W., Speshock, J.L., Hussain, S.M.: A preliminary assessment of silver nanoparticle inhibition of monkeypox virus plaque formation. Nanoscale Res. Lett. 3, 129–133 (2008). https://doi.org/10.1007/s11671-008-9128-2
Shady, N.H., Khattab, A.R., Ahmed, S., Liu, M., Quinn, R.J., Fouad, M.A., Kamel, M.S., Muhsinah, A.B., Krischke, M., Mueller, M.J., Abdelmohsen, U.R.: Hepatitis C virus NS3 protease and helicase inhibitors from red sea sponge (Amphimedon) species in green synthesized silver nanoparticles assisted by in silico modeling and metabolic profiling. Int. J. Nanomedicine 15, 3377–3389 (2020). https://doi.org/10.2147/IJN.S233766
Sharma, R.K., Cwiklinski, K., Aalinkeel, R., Reynolds, J.L., Sykes, D.E., Quaye, E., Oh, J., Mahajan, S.D., Schwartz, S.A.: Immunomodulatory activities of curcumin-stabilized silver nanoparticles: Efficacy as an antiretroviral therapeutic. Immunol. Invest. 46, 833–846 (2017). https://doi.org/10.1080/08820139.2017.1371908
Speshock, J.L., Murdock, R.C., Braydich-Stolle, L.K., Schrand, A.M., Hussain, S.M.: Interaction of silver nanoparticles with Tacaribe virus. J. Nanobiotechnology 8, 1–9 (2010). https://doi.org/10.1186/1477-3155-8-19
Sun, R.W.Y., Chen, R., Chung, N.P.Y., Ho, C.M., Lin, C.L.S., Che, C.M.: Silver nanoparticles fabricated in Hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells. Chem. Commun. 5059–5061 (2005). https://doi.org/10.1039/b510984a
Sun, L., Singh, A., Vig, K., Pillai, S.R., Singh, S.R.: Silver Nanoparticles Inhibit Replication of Respiratory Syntical Virus. J. Biomed. Nanotechnol 4, 149–158 (2008)
Tsai, C.H., Whiteley, C.G., Lee, D.J.: Interactions between HIV-1 protease, silver nanoparticles, and specific peptides. J. Taiwan Inst. Chem. Eng. 103, 20–32 (2019). https://doi.org/10.1016/j.jtice.2019.07.019
Whiteley, C.G., Shing, C.Y., Kuo, C.C., Lee, D.J.: Docking of HIV protease to silver nanoparticles. J. Taiwan Inst. Chem. Eng. 60, 83–91 (2016). https://doi.org/10.1016/j.jtice.2015.10.029
WHO: COVID-19 vaccine development, Coronavirus Update 37 (2020)
Xiang, D.X., Chen, Q., Pang, L., Zheng, C.L.: Inhibitory effects of silver nanoparticles on H1N1 influenza A virus in vitro. J. Virol. Methods 178, 137–142 (2011). https://doi.org/10.1016/j.jviromet.2011.09.003
Xiang, D., Zheng, Y., Duan, W., Li, X., Yin, J., Shigdar, S., O’Connor, M.L., Marappan, M., Zhao, X., Miao, Y., Xiang, B., Zheng, C.: Inhibition of A/Human/Hubei/3/2005 (H3N2) influenza virus infection by silver nanoparticles in vitro and in vivo. Int. J. Nanomedicine 8, 4103–4114 (2013). https://doi.org/10.2147/IJN.S53
Yang, X.X., Li, C.M., Huang, C.Z.: Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection. Nanoscale 8, 3040–3048 (2016). https://doi.org/10.1039/c5nr07918g
Zoulim, F.: Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic Hepatitis B virus infection. Antiviral Res. 64, 1–15 (2004). https://doi.org/10.1016/j.antiviral.2004.07.003
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Lal, H.M., Uthaman, A., Thomas, S. (2021). Silver Nanoparticle as an Effective Antiviral Agent. In: Lal, H.M., Thomas, S., Li, T., Maria, H.J. (eds) Polymer Nanocomposites Based on Silver Nanoparticles. Engineering Materials. Springer, Cham. https://doi.org/10.1007/978-3-030-44259-0_10
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DOI: https://doi.org/10.1007/978-3-030-44259-0_10
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