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Modelling Hepatitis C Infections Among People Who Inject Drugs in Turkey: Is HCV Elimination Possible?

  • Emine YaylaliEmail author
  • Busra Ozdemir
  • Neslihan Lacin
  • Sumeye Ceyil
Conference paper
  • 24 Downloads
Part of the Lecture Notes in Management and Industrial Engineering book series (LNMIE)

Abstract

Hepatitis C (HCV) is one of the major infectious diseases in the world. Injection drug users (PWID) is a population who is at higher risk of acquisition of HCV due to risky behaviors such as needle sharing, and they are considered as an important factor in the spread of the disease. World Health Organization (WHO) aims to eliminate hepatitis C disease by 2030 with the help of approval and dissemination of newly developed direct-acting antiviral treatment regimes. In this study, we evaluated the cost-effectiveness of hepatitis C treatment among injected drug users in Turkey to observe whether it is possible to reach WHO targets. Purpose of our model is to determine the infected population in the future, and we simulated the injected drug user population with a time horizon of 20 years. We developed five scenarios to represent different levels of treatment coverage. We included treatment regimens that are available in Turkey and that are reimbursed by the government health care insurance policies, which roughly covers over 90% of the Turkish population. Our model objective is (i) to predict the spread of HCV in the next 20 years, (ii) to determine the cost of new treatment regimens available to Turkish PWID population and (iii) to estimate the cost-effectiveness of these regimes. Our results indicate that HCV infected PWIDs could significantly decrease with treatment while the lowest total cost of treatment could be achieved with Viekirax Exviera and Mavyret. Also, it is possible to reach WHO targets by 2030 in Turkey if the treatment coverage increases.

Keywords

SIR model Hepatitis C Injection drug users Cost-effectiveness 

References

  1. Alaei A, Alaei K, Waye K, Tracy M, Nalbandyan M, Mutlu E, Cetin MK (2017) Hepatitis C infection and other drug-related harms among inpatients who injected drugs in Turkey. J Viral Hepatitis 24:496–505.  https://doi.org/10.1111/jvh.12662CrossRefGoogle Scholar
  2. Bağımlılık Yapıcı Maddeler ve Bağımlılık Ile Mücadele 2007 Yılı Ulusal Raporu (2007) http://www.emcdda.europa.eu/system/files/publications/942/NR2007Tureky_tr.pdf
  3. Bayer College of Medicine (n.d.) Introduction to infectious diseases. https://www.bcm.edu/departments/molecular-virology-and-microbiology/emerging-infections-and-biodefense/introduction-to-infectious-diseases. Accessed 10 Mar 2019
  4. Van Den Berg CHSB, Smit C, Bakker M, Geskus RB, Berkhout B, Jurriaans S, Coutinho RA, Wolthers KC, Prins M (2007) Major decline of hepatitis C virus incidence rate over two decades in a cohort of drug users. Eur J Epidemiol.  https://doi.org/10.1007/s10654-006-9089-7CrossRefGoogle Scholar
  5. Centers for Disease Control and Prevention (n.d.) What is the recommended management of a health care worker with occupational exposure to HCV? https://www.cdc.gov/hepatitis/hcv/hcvfaq.htm#Ref24
  6. Chhatwal J, Kanwal F, Roberts MS, Dunn MA (2015) Cost-effectiveness and budget impact of hepatitis C virus treatment with sofosbuvir and ledipasvir in the United States. Ann Intern Med. Author Manuscrip 162(6):397–406.  https://doi.org/10.1097/CCM.0b013e31823da96d.HydrogenCrossRefGoogle Scholar
  7. Cipriano LE, Zaric GS, Holodniy M, Bendavid E, Owens DK, Brandeau ML (2012) Cost effectiveness of screening strategies for early identification of HIV and HCV infection in injection drug users. PLoS ONE 7(9).  https://doi.org/10.1371/journal.pone.0045176CrossRefGoogle Scholar
  8. Eastern Europe Population (n.d.) Worldometers. https://www.worldometers.info/population/europe/eastern-europe/. Accessed 10 Feb 2019
  9. Evren C, Tamar D, Ögel K (1996) Damar Yolu Ile Eroin Kullanımı ve İlişkili Bazı Davranış Biçimleri. http://www.ogelk.net/Dosyadepo/damar4.pdf
  10. Grassly NC, Fraser C (2006) Seasonal infectious disease epidemiology. Proc R Soc B Biol Sci.  https://doi.org/10.1098/rspb.2006.3604CrossRefGoogle Scholar
  11. Grebely J, Dore GJ (2011) Prevention of hepatitis C virus in injecting drug users: a narrow window of opportunity. J Infect Dis.  https://doi.org/10.1093/infdis/jiq111CrossRefGoogle Scholar
  12. Hagan H, McGough JP, Thiede H, Weiss NS, Hopkins S, Russell E (1999) Syringe exchange and risk of infection with hepatitis B and C viruses. Am J Epidemiol 149(3):381.  https://doi.org/10.1016/S0041-3879(38)80113-6CrossRefGoogle Scholar
  13. Hagan H, Pouget ER, Williams IT, Garfein RL, Strathdee SA, Hudson SM, Latka MH, Ouellet LJ (2010) Attribution of hepatitis C virus seroconversion risk in young injection drug users in 5 US cities. J Infect Dis 201(3):378–385.  https://doi.org/10.1086/649783CrossRefGoogle Scholar
  14. He T, Li K, Roberts MS, Spaulding AC, Ayer T, Grefenstette JJ, Chhatwal J (2015) Prevention of hepatitis C by screening and treatment in U.S. prisons. Ann Intern Med.  https://doi.org/10.7326/M15-0617CrossRefGoogle Scholar
  15. Hepatitis C and Health Care Personnel (n.d.) Centers for disease control and prevention. https://www.cdc.gov/hepatitis/hcv/hcvfaq.htm. Accessed 1 Jan 2019
  16. Herkesin Başına Gelebilir. Hep C ve B… ve Biz (n.d.) PrometheeGoogle Scholar
  17. Hethcote HW (2000) The mathematics of infectious diseases. SIAM Rev 42(4):599–653MathSciNetCrossRefGoogle Scholar
  18. Irmak H, Yardım N, Keklik K, Temel F (n.d.) Türkiye Viral Hepatit Önleme ve Kontrol Programı 2018–2023. https://hsgm.saglik.gov.tr/depo/birimler/Bulasici-hastaliklar-. Accessed 1 Jan 2019
  19. Kretzschmar M, Wallinga J (2010) Modern infectious disease epidemiology: concepts, methods, mathematical models, and public health. Krämer A, Gail M, Tsiatis A, Krickeberg K, Samet JM, Wong W, Kretzschmar M (eds). Springer, New York.  https://doi.org/10.1016/s0035-9203(02)90396-2CrossRefGoogle Scholar
  20. Maor Y, Malnick SDH, Melzer E, Leshno M (2016) Treatment of chronic hepatitis C in the aged - does it impact life expectancy? A decision analysis. PLoS ONE.  https://doi.org/10.1371/journal.pone.0157832CrossRefGoogle Scholar
  21. Mathers BM, Degenhardt L, Phillips B, Wiessing L, Hickman M, Strathdee SA, Wodak A et al (2008) Global epidemiology of injecting drug use and HIV among people who inject drugs: a systematic review. Lancet.  https://doi.org/10.1016/S0140-6736(08)61311-2CrossRefGoogle Scholar
  22. Ögel K, Tamar D, Evren C, Hızlan C (n.d.) Madde Kullanıcılarının Özellı̇klerı̇: Türkiye’de Çok Merkezli Bir Araştırma (İkinci Aşama)Google Scholar
  23. Örmeci N, Malhan S, Balık İ, Ergör G, Razavi H, Robbins S (2017) Scenarios to manage the hepatitis C disease burden and associated economic impact of treatment in Turkey. Hep Intl 11:509–516.  https://doi.org/10.1007/s12072-017-9820-3CrossRefGoogle Scholar
  24. Perz JF, Armstrong GL, Farrington LA, Hutin YJF, Bell BP (2006) The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol.  https://doi.org/10.1016/j.jhep.2006.05.013CrossRefGoogle Scholar
  25. Pfeil AM, Reich O, Guerra IM, Cure S, Negro F, Müllhaupt B, Lavanchy D, Schwenkglenks M (2015) Cost-effectiveness analysis of sofosbuvir compared to current standard treatment in Swiss patients with chronic hepatitis C. PLoS ONE 10(5):1–20.  https://doi.org/10.1371/journal.pone.0126984CrossRefGoogle Scholar
  26. Pınarcı M (2009) Bağımlılık Yapıcı Maddeler ve Bağımlılık Ile Mücadele 2009 Yılı Ulusal RaporuGoogle Scholar
  27. Population: Central Asia (n.d.) WorldometersGoogle Scholar
  28. Poynard T, Bedossa P, Opolon P (1997) Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet.  https://doi.org/10.1016/S0140-6736(96)07642-8CrossRefGoogle Scholar
  29. Scott N, Iser DM, Thompson AJ, Doyle JS, Hellard ME (2016) Cost-effectiveness of treating chronic hepatitis C virus with direct-acting antivirals in people who inject drugs in Australia. J Gastroenterol Hepatol (Australia) 31(4):872–882.  https://doi.org/10.1111/jgh.13223CrossRefGoogle Scholar
  30. Side S, Noorani SMd (2013) A SIR model for spread of dengue fever disease (simulation for South Sulawesi, Indonesia and Selangor, Malaysia). World J Model Simul 9(2):96–105.  https://doi.org/10.2523/iptc-14328-msCrossRefGoogle Scholar
  31. Stone L, Shulgin B, Agur Z (2000) Theoretical examination of the pulse vaccination policy in the SIR epidemic model. Math Comput Model 31:207–215.  https://doi.org/10.1016/S0895-7177(00)00040-6MathSciNetCrossRefzbMATHGoogle Scholar
  32. Strathdee SA, Hallett TB, Bobrova N, Rhodes T, Booth R, Abdool R, Hankins CA (2010) HIV and risk environment for injecting drug users: the past, present, and future. Lancet.  https://doi.org/10.1016/S0140-6736(10)60743-XCrossRefGoogle Scholar
  33. Thomas DL, Vlahov D, Solomon L, Cohn S, Taylor E, Garfein R, Nelson KE (1995) Correlates of hepatitis C virus infections among injection drug users. Medicine (United States).  https://doi.org/10.1097/00005792-199507000-00005CrossRefGoogle Scholar
  34. Thorpe LE, Ouellet LJ, Hershow R, Bailey SL, Williams IT, Williamson J, Monterroso ER, Garfein RS (2002) Risk of hepatitis C virus infection among young adult injection drug users who share injection equipment. Am J Epidemiol.  https://doi.org/10.1093/aje/155.7.645CrossRefGoogle Scholar
  35. Tsoulfas G, Goulis I, Giakoustidis D, Akriviadis E, Agorastou P, Imvrios G, Papanikolaou V (2009) Hepatitis C and liver transplantation. Hippokratia 13(4):211Google Scholar
  36. Türkcan A (1998) Türkiye’de Madde Kullananlar In Profili: Hastane Verilerinin Incelenmesi. Düşünen AdamGoogle Scholar
  37. Türkiye İstatistik Kurumu (TUIK) (2018) Adrese Dayalı Nüfus Kayıt Sistemi Sonuçları, 2017 (2018) http://www.tuik.gov.tr/PreHaberBultenleri.do?id=27587%0D
  38. Türkı̇ye Uyuşturucu ve Uyuşturucu Bağımlılığı İzleme Merkezi (TUBİM) (2013)Google Scholar
  39. Viral Hepatitis (n.d.) Centers for disease control and preventionGoogle Scholar
  40. Wandrer F, Han B, Liebig S, Schlue J, Manns MP, Schulze-Osthoff K, Bantel H (2018) Senescence mirrors the extent of liver fibrosis in chronic hepatitis C virus infection. Aliment Pharmacol Ther.  https://doi.org/10.1111/apt.14802CrossRefGoogle Scholar
  41. Western Europe Population (n.d.) Worldometers. https://www.worldometers.info/world-population/western-europe-population/. Accessed 10 Feb 2019
  42. World Drug Report (2004) New YorkGoogle Scholar
  43. World Health Organization (n.d.) Combating hepatitis B and C to reach elimination by 2030. https://www.who.int/hepatitis/publications/hep-elimination-by-2030-brief/en/. Accessed 10 Jan 2019
  44. World Health Organization (2018) Hepatitis C (2018) https://www.who.int/news-room/fact-sheets/detail/hepatitis-c
  45. Yusuf TT, Francis B (2012) Optimal control of vaccination and treatment for an SIR epidemiological model. World J Model Simul 8(3):194–204 http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.571.8340&rep=rep1&type=pdfGoogle Scholar
  46. Zeremski M, DImova RB, Pillardy J, De Jong YP, Jacobson IM, Talal AH (2016) Fibrosis progression in patients with chronic hepatitis C virus infection. J Infect Dis.  https://doi.org/10.1093/infdis/jiw332CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Emine Yaylali
    • 1
    Email author
  • Busra Ozdemir
    • 1
  • Neslihan Lacin
    • 1
  • Sumeye Ceyil
    • 1
  1. 1.Industrial Engineering Department, Management FacultyIstanbul Technical UniversityIstanbulTurkey

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