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Comparative Performance Analysis of Different Measures to Select Disease Related Informative Genes from Microarray Gene Expression Data

  • Chandra Das
  • Shilpi BoseEmail author
  • Abhik Banerjee
  • Sourav Dutta
  • Kuntal Ghosh
  • Matangini Chattopadhyay
Conference paper
  • 74 Downloads
Part of the Learning and Analytics in Intelligent Systems book series (LAIS, volume 12)

Abstract

Diseased sample classification is a very important application of microarray gene expression data. For sample classification the main problem is high dimensionality of genes (features). Among those huge numbers of genes only a small number of genes carry disease related information. To improve sample classification accuracy gene dimension reduction by selecting informative and non-redundant genes is a necessary task and for this purpose different feature selection methodologies are applied. In this regard, here, a comparative study of different measures to select informative and non-redundant genes is carried out. The effectiveness of different measures is assessed based on classification accuracy of different classifiers by applying them on different microarray gene expression datasets.

Keywords

Classification Microarray gene expression data Feature selection Univariate filter t-test Fisher score Chi square Mutual information ReliefF Symmetric uncertainty 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Chandra Das
    • 1
  • Shilpi Bose
    • 1
    Email author
  • Abhik Banerjee
    • 1
  • Sourav Dutta
    • 1
  • Kuntal Ghosh
    • 2
  • Matangini Chattopadhyay
    • 3
  1. 1.Department of Computer Science and EngineeringNetaji Subhash Engineering CollegeKolkataIndia
  2. 2.Machine Intelligence UnitIndian Statistical InstituteKolkataIndia
  3. 3.School of Education TechnologyJadavpur UniversityKolkataIndia

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