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Iron Oxide Magnetic Nanoparticles (NPs) Tailored for Biomedical Applications

  • Giorgio ZoppellaroEmail author
Chapter
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Part of the Nanomedicine and Nanotoxicology book series (NANOMED)

Abstract

Many variables need to be considered and implemented in the NP systems when these nanostructured magnetic materials are tailored for biological applications. In this chapter, we discuss the chemical basis that drives the selection of magnetic cores and outer shell compositions, sizes, morphologies, to improve NP stability, low cytotoxicity, and circulation time. Toxicity effects are dissected, with emphasis on metal metabolism and ROS generation. NP biodistribution is analyzed, as well as the possible interactions between NPs with cells, proteins, and redox molecules present in vitro and in vivo experiments that can alter and limit NP functions as contrast agent materials and as vectors in drug delivery.

Keywords

Synthetic methods Magnetic nanoparticles Nanomaterial’s metabolism Nanomaterial’s biodistribution Medical applications 

Notes

Acknowledgements

The author thanks the support from the Ministry of Education, Youth, and Sports of the Czech Republic under Project No. LO1305. The work was also supported by the ERDF project “Development of pre-applied research in nanotechnology and biotechnology” (No. CZ.02.1.01/0.0/0.0/17_048/0007323).

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Physical Chemistry, Faculty of Science, Regional Centre of Advanced Technologies and MaterialsPalacky University in OlomoucOlomoucCzech Republic

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