Bone Cement pp 69-88 | Cite as

Inductivity: Bioactive Agents

  • Hamid Reza RezaieEmail author
  • Mohammad Hossein Esnaashary
  • Masoud Karfarma
  • Andreas Öchsner
Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)


In bone tissue engineering, besides osteoconductivity and productivity, inducing the cells surrounded implanted scaffold via bioactive agents is crucial. To apply this property to bone tissue engineering, researchers are inspired by natural events which are occurring during bone healing. In addition to the role of various cells involved in bone healing, some bioactive agents such as inflammatory, angiogenic, and osteogenic growth factor take part in the process and control the events. Based on this strategy, in this chapter, the bone healing process is discussed in the context of employing various bioactive agents, including growth factors, drugs, and nucleic acids. Furthermore, the incorporation methods of the agents into a scaffold are investigated. In the last part of this chapter, common challenges that deal with bone tissue engineering are addressed.


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Copyright information

© The Author(s), under exclusive license to Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Hamid Reza Rezaie
    • 1
    Email author
  • Mohammad Hossein Esnaashary
    • 1
  • Masoud Karfarma
    • 1
  • Andreas Öchsner
    • 2
  1. 1.Ceramic and Biomaterial Division, Department of Engineering MaterialsIran University of Science and TechnologyTehranIran
  2. 2.Faculty of Mechanical EngineeringEsslingen University of Applied SciencesEsslingen am NeckarGermany

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