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Sperm DNA Fragmentation: Treatment Options and Evidence-Based Medicine

  • Ahmad Majzoub
  • Mohamed Arafa
  • Haitham Elbardisi
  • Ashok Agarwal
Chapter
  • 72 Downloads

Abstract

Sperm DNA fragmentation testing has been recognized as an important additive evaluation tool for examining male fertility potential. This is because SDF can significantly influence fertilization, embryogenesis, and live birth rate. Several indications for SDF testing have been recently recognized. Once detected, the SDF level can aid the clinician in making sound decisions in attempting to normalize the SDF value and improve a man’s fertility status. Treatments such as frequent ejaculations, treatment of infection, avoidance of risk factors, antioxidant therapy, varicocelectomy, sperm selection, and use of testicular sperm for intracytoplasmic sperm injection have been utilized with promising results.

Keywords

Sperm DNA fragmentation Male infertility Oxidative stress 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Ahmad Majzoub
    • 1
  • Mohamed Arafa
    • 1
  • Haitham Elbardisi
    • 1
  • Ashok Agarwal
    • 2
  1. 1.Department of UrologyHamad Medical CorporationDohaQatar
  2. 2.Cleveland ClinicClevelandUSA

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