Fibroblasts in the Tumor Microenvironment

  • Marta Truffi
  • Luca Sorrentino
  • Fabio CorsiEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1234)


The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as matrix and soluble factors. A switch from quiescent fibroblasts to cancer-associated fibroblasts triggers a large variety of pro-tumorigenic signals that support tumor progression and shape the surrounding pathological stroma, with the remodeling of tissue architecture and repression of the local immune response. The heterogeneous nature of cancer-associated fibroblasts and their multiple functions are subject of active research as they could represent promising targets for cutting-edge therapeutic approaches to cancer and the tumor microenvironment.


Cancer-associated fibroblasts Epithelial-to-mesenchymal transition Tumor microenvironment Pro-tumorigenic cytokines Extracellular matrix remodeling Tumor neoangiogenesis Immunosuppression Cancer-stroma crosstalk Chemoresistance Targeted therapy Cancer treatment 



The authors thank Associazione Italiana per la Ricerca sul Cancro for research support (AIRC IG 20172 to F.C.)


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Istituti Clinici Scientifici Maugeri IRCCSPaviaItaly
  2. 2.Department of Biomedical and Clinical Sciences “Luigi Sacco”Università degli studi di MilanoMilanoItaly

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