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TH Treatment in Patients with Cardiac Disorders: General Aspects and Rationale

  • Laura SabatinoEmail author
Chapter
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Abstract

Thyroid hormones (TH) are the principal modulators of cardiovascular homeostasis in both physiological and pathological conditions, mainly regulating heart rate, cardiac contractility, and vascular resistance, by genomic and non-genomic activities. In the present chapter, are discussed the most important events characterizing the TH regulation of the cardiac muscle at molecular and cellular levels. In particular, are considered the TH reduction observed in some pathological conditions and the switch from beneficial to progressively harmful effects. Moreover, is evaluated the importance of epigenetic modifications related to TH signaling in a cardiac context. Based on these observations, the possible cardiac role of TH and its potential clinical and therapeutical relevance will be discussed.

Keywords

Thyroid hormones Cardiovascular system Cardiovascular homeostasis Cardiac remodeling Epigenetic 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Institute of Clinical Physiology CNRPisaItaly

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