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Deep Brain Stimulation for Depression

  • Isidoor O. Bergfeld
  • Martijn FigeeEmail author
Chapter
  • 29 Downloads

Abstract

Open-label studies of deep brain stimulation (DBS) for patients with treatment-resistant depression (TRD) are promising: approximately 40% of patients lose at least half of their symptoms following DBS of the subcallosal cingulate cortex (SCC) or ventral capsule and ventral striatum (VC/VS). The results of sham-controlled trials, however, have been mixed so far and show much room for optimization. For instance, targeting specific white matter bundles shows a lot of potential, with at least 70% of patients responding to targeting of patient-specific SCC bundles or the medial forebrain bundle. Exploring the additional value of rehabilitation and cognitive behavioral programs, as well as optimizing parameter selection, could further optimize the treatment.

Keywords

Deep brain stimulation DBS Treatment refractory depression TRD Efficacy Safety Mechanisms 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Psychiatry, Amsterdam NeuroscienceAmsterdam University Medical Center, University of AmsterdamAmsterdamThe Netherlands
  2. 2.Amsterdam Brain and CognitionAmsterdamThe Netherlands
  3. 3.Department of PsychiatryIcahn School of Medicine at Mount SinaiNew YorkUSA

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