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Oral Vaccine Delivery: The Coming Age of Particulate Vaccines to Elicit Mucosal Immunity

  • Rikhav P. Gala
  • Lotika Bajaj
  • Amit Bansal
  • Keegan Braz Gomes
  • Devyani Joshi
  • Ipshita Menon
  • Rokon Uz Zaman
  • Susu M. Zughaier
  • Marissa D’Souza
  • Carmen Popescu
  • Nigel D’Souza
  • Gregory T. Knipp
  • Martin J. D’SouzaEmail author
Chapter
  • 35 Downloads
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 41)

Abstract

With the evolution of different challenging diseases, there is an urgent need of vaccine development against them to save millions of lives around the world. Particlulate delivery system plays an important role by acting as self-adjuvant in form of particles and thus assisting the immunogenicity of vaccines. Particulate vaccines have shown to have improved uptake by antigen presenting cells as compared to the soluble antigen. Traditional injectable vaccines are generally poor inducers of mucosal immunity and are therefore less effective against infections at the mucosal site. Mucosal vaccines have been reported to provide additional secretory antibody mediated protection at the mucosal site of entry of the pathogen. In this chapter, we discuss the benefits of particulate drug delivery systems for oral delivery, the role of immune system in the gut, and a case study ofa novel particulate vaccine formulated into oral dissolving film for immunization via the buccal route. Key formulation components, process parameters and their biophysical characterizations have been discussed as well.

Keywords

Microparticles Spray dry Oral dissolving films Mucosal immunity Buccal immunization 

Abbreviations

APCs

Antigen-Presenting Cells

BBB

Blood-Brain Barrier

BSA

Bovine Serum Albumin

DCs

Dendritic Cells

EPR

Enhanced Permeability and Retention

GALT

Gut Associated Lymphoid Tissue

IFNϒ

Interferon Gamma

IL

Interleukin

MHC

Major Histocompatibility Complex

MLNs

Mesenteric Lymph Nodes

MALT

Mucosal Associate Lymphoid Tissues

MIS

Mucosal Immune System

NALT

Nasopharynx-Associated Lymphoid Tissue

ODF

Oral Dissolving Film

PPs

Peyer’s Patches

PLGA

Poly(lLactic-cCo-gGlycolic aAcid)

RVG

Rabies Virus Glycoprotein

TLRs

Toll-Like Receptors

Th1

Type 1 Helper T Cells

Th2

Type 2 Helper T Cells

VLPs

Virus-Like Particles

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Copyright information

© American Association of Pharmaceutical Scientists 2020

Authors and Affiliations

  • Rikhav P. Gala
    • 1
    • 2
  • Lotika Bajaj
    • 1
  • Amit Bansal
    • 1
  • Keegan Braz Gomes
    • 1
  • Devyani Joshi
    • 1
  • Ipshita Menon
    • 1
  • Rokon Uz Zaman
    • 1
  • Susu M. Zughaier
    • 3
  • Marissa D’Souza
    • 1
  • Carmen Popescu
    • 4
  • Nigel D’Souza
    • 1
  • Gregory T. Knipp
    • 5
  • Martin J. D’Souza
    • 1
    Email author
  1. 1.Vaccine Nanotechnology Laboratory, Center for Drug DeliveryMercer UniversityAtlantaUSA
  2. 2.Department of Pharmaceutical SciencesUniversity of New MexicoAlbuquerqueUSA
  3. 3.College of MedicineQatar UniversityDohaQatar
  4. 4.Roquette America Inc.GenevaUSA
  5. 5.Department of Industrial and Physical PharmacyCollege of Pharmacy, Purdue UniversityWest LafayetteUSA

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