Bioresorbable Nano-Hydroxyapatite Reinforced Magnesium Alloplastic Bone Substitute for Biomedical Applications: A Study

  • Somasundaram Prasadh
  • Vyasaraj Manakari
  • Gururaj Parande
  • T. S. Srivatsan
  • Raymond WongEmail author
  • Manoj Gupta
Conference paper
Part of the The Minerals, Metals & Materials Series book series (MMMS)


Biodegradable magnesium, when reinforced with nanoparticles, displays significant improvements in its mechanical strength, cell proliferation, and corrosion resistance when compared to existing commercially available alloys. This inimitable behavior of magnesium-based composites makes it a unique offering in orthopedic and mandibular reconstruction applications. Additionally, it displays mechanical properties similar to the natural bone highlighting its huge potential as an orthopedic implant material. The present study focuses on the influence of hydroxyapatite (HA) nanoparticles on mechanical, immersion and cytocompatibility properties of magnesium processed by powder metallurgy technique coupled with hybrid microwave sintering. The inclusion of HA nanoreinforcement restricted the growth of grain size for Mg, thereby resulting in superior biodegradation and biocompatibility properties. Mg–HA nanocomposites displayed excellent corrosion resistance compared to its matrix counterpart showing a near-uniform degradation rate. MC3T3-E1 cells showed an increased cell viability percentage and subsequent low cytotoxicity levels. No obvious toxic effects were observed, which is consistent with the enhanced corrosion resistance of Mg alloys resulting in better cell attachment and viability. Structure–property correlations are drawn and analyzed.


Magnesium matrix composites Corrosion Biodegradability Cytocompatibility Orthopedic and mandibular reconstruction 


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Copyright information

© The Minerals, Metals & Materials Society 2019

Authors and Affiliations

  • Somasundaram Prasadh
    • 1
  • Vyasaraj Manakari
    • 2
  • Gururaj Parande
    • 2
  • T. S. Srivatsan
    • 3
  • Raymond Wong
    • 1
    Email author
  • Manoj Gupta
    • 2
  1. 1.Faculty of DentistryNational University of SingaporeSingaporeSingapore
  2. 2.Department of Mechanical EngineeringNational University of SingaporeSingaporeSingapore
  3. 3.Department of Mechanical EngineeringThe University of AkronAkronUSA

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