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Tumor Microenvironment Conditioning by Abortive Lytic Replication of Oncogenic γ-Herpesviruses

Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1225)

Abstract

Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) constitute the human γ-herpesviruses and two of the seven human tumor viruses. In addition to their viral oncogenes that primarily belong to the latent infection programs of these viruses, they encode proteins that condition the microenvironment. Many of these are early lytic gene products and are only expressed in a subset of infected cells of the tumor mass. In this chapter I will describe their function and the evidence that targeting them in addition to the latent oncogenes could be beneficial for the treatment of EBV- and KSHV-associated malignancies.

Keywords

Kaposi sarcoma-associated herpesvirus Epstein Barr virus Viral IL-6 Viral IL-10 Viral MIP Viral miRNA CCL5 Lytic replication Angiogenesis Kaposi sarcoma Primary effusion lymphoma Multicentric Castleman’s disease Hodgkin’s lymphoma Burkitt’s lymphoma Nasopharyngeal carcinoma 

Notes

Acknowledgments

Research in my laboratory is supported by Cancer Research Switzerland (KFS-4091-02-2017), KFSP-PrecisionMS of the University of Zurich, the Vontobel Foundation, the Baugarten Foundation, the Sobek Foundation, the Swiss Vaccine Research Institute, the Swiss MS Society, Roche, ReiThera, and the Swiss National Science Foundation (310030B_182827 and CRSII5_180323).

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Authors and Affiliations

  1. 1.Viral Immunobiology, Institute of Experimental ImmunologyUniversity of ZürichZürichSwitzerland

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