Lesion-Symptom Mapping in Speech and Language Disorders: A Translational Perspective

  • Georgios P. D. Argyropoulos
Part of the Contemporary Clinical Neuroscience book series (CCNE)


Modern lesion-symptom mapping methods offer highly sophisticated ways of identifying particular regions and networks, disruptions in which are causally associated with specific speech and language deficits. The translational insight afforded from these approaches is highly promising for improved patient care. This chapter briefly describes the history of and the major advances in the field, highlights the translational possibilities of advanced lesion-symptom mapping, and identifies challenges and future directions for these endeavors.


Lesion-symptom mapping Stroke MRI 



Computed tomography


Functional magnetic resonance imaging


Lesion-symptom mapping


Magnetic resonance imaging


Non-parametric mapping


Predict language outcome and recovery after stroke


Transcranial direct current stimulation


Transcranial magnetic stimulation


Voxel-based lesion-behavior mapping


Voxel-based lesion-symptom mapping


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Further Reading

  1. Baldo, J. V., Wilson, S. M., & Dronkers, N. F. (2012). Uncovering the neural substrates of language: A voxel-based lesion–symptom mapping approach. The Handbook of the Neuropsychology of Language, 2, 582-594.CrossRefGoogle Scholar
  2. Bates, E., Wilson, S. M., Saygin, A. P., Dick, F., Sereno, M. I., Knight, R. T., & Dronkers, N. F. (2003). Voxel-based lesion-symptom mapping. Nature Neuroscience, 6, 448–450.CrossRefGoogle Scholar
  3. Price, C. J., Hope, T. M., & Seghier, M. L. (2017). Ten problems and solutions when predicting individual outcome from lesion site after stroke. Neuroimage, 145, 200–208.CrossRefGoogle Scholar
  4. Price, C. J., Seghier, M. L., & Leff, A. P. (2010). Predicting language outcome and recovery after stroke: the PLORAS system. Nature Reviews Neurology, 6, 202–210.CrossRefGoogle Scholar
  5. Pustina, D., Avants, B., Faseyitan, O. K., Medaglia, J. D., & Coslett, H. B. (2018). Improved accuracy of lesion to symptom mapping with multivariate sparse canonical correlations. Neuropsychologia, 115, 154–166.CrossRefGoogle Scholar
  6. Rorden, C., Karnath, H.-O., & Bonilha, L. (2007). Improving lesion-symptom mapping. Journal of Cognitive Neuroscience, 19, 1081–1088.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Georgios P. D. Argyropoulos
    • 1
  1. 1.Nuffield Department of Clinical NeurosciencesJohn Radcliffe Hospital University of OxfordOxfordUK

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