The Pathophysiologic Events of Total Joint Replacement Surgery

  • Stavros G. MemtsoudisEmail author


Patients undergoing orthopedic surgery are subject to many perioperative insults. Unique to this patient population however is the intravasation of bone, cement, and marrow during the surgical instrumentation process that occurs frequently and may contribute to the pathophysiology of complications seen in the perioperative period. The risk of perioperative complications may be dependent on the level of the operative insult on one hand and end-organ reserve on the other. Identifying interventions that can reduce perioperative insults and instituting programs to identify patients at risk may result in a decrease in the odds for perioperative complications. This chapter explores possible sources of injury and related processes and attempts to relate them to complications frequently seen in orthopedic patients.


Pathophysiology Complications Bone cement syndrome 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of AnesthesiologyCritical Care and Pain Management, Hospital for Special Surgery-Weill Cornell MedicineNew YorkUSA

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