Evaluating the Efficacy of Adult HIV Post Exposure Prophylaxis Regimens in Relation to Transmission Risk Factors by Multi Criteria Decision Method

  • Murat Sayan
  • Tamer Sanlidag
  • Nazife Sultanoglu
  • Berna UzunEmail author
  • Figen Sarigul Yildirim
  • Dilber Uzun Ozsahin
Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 1095)


There are approximately 39 million people living with the human immunodeficiency virus (HIV) worldwide. Although antiretroviral treatment (ART) has revolutionized the treatment and management of the HIV infection, a cure still remains elusive. In addition to ART’s success at prolonging the lives of the infected individuals, it also has its uses in other cases. For example, post exposure prophylaxis (PEP) ART regimens are used after potential exposure to HIV to prevent the establishment of the HIV infection by up to 80% when administered in a timely manner. There are many guidelines available for these situations; however, they have differences in terms of their content and very few guidelines suggest specific PEP ART regimens for particular risk factors. Our study uses a multi criteria decision making method called Fuzzy PROMETHEE to evaluate the effectiveness of selected PEP ART regimens according to specified transmission risk factors for HIV. The risk factors were the criteria in this study and were weighted according to experts’ opinions in terms of their relative importance.


Multi criteria decision method Fuzzy PROMETHEE HIV Risk factors Adult post exposure prophylaxis regimen 


  1. 1.
    WHO: The Discovery and Development of Antiretroviral Agents. Accessed 16 May 2019
  2. 2.
  3. 3.
    AIDSinfo: HIV Treatment: The Basics Understanding HIV/AIDS.–the-basics. Accessed 16 May 2019
  4. 4.
    Sultan, B., Benn, P., Waters, L.: Current perspectives in HIV post-exposure prophylaxis. HIV AIDS (Auckl) 6, 147 (2014)Google Scholar
  5. 5.
    WHO: Guidelines on post-exposure prophylaxis for HIV and the use of co-trimoxazole prophylaxis for HIV-related infections among adults, adolescents and children. World Health Organization (2014)Google Scholar
  6. 6.
    CDC: Updated Guidelines for Antiretroviral Postexposure Prophylaxis After Sexual, Injection-Drug Use, or Other Nonoccupational Exposure to HIV, United States (2016)Google Scholar
  7. 7.
    WHO: Post-exposure prophylaxis to prevent HIV infection, WHO. Accessed 13 Dec 2018
  8. 8.
    Sultanoglu, N., Uzun, B., Yildirim, F.S., Sayan, M., Sanlidag, T., Ozsahin, D.U.: Selection of the most appropriate antiretroviral medication in determined aged groups (≥3 years) of HIV-1 infected children. In: Advances in Science and Engineering Technology International Conferences (ASET), pp. 1–6. IEEE Xplorer, Dubai (2019)Google Scholar
  9. 9.
    Sayan, M., Sultanoglu, N., Uzun, B., Yildirim, F.S., Sanlidag, T., Ozsahin, D.U.: Determination of post-exposure prophylaxis regimen in the prevention of potential pediatric HIV-1 infection by the multi-criteria decision making theory. In: Advances in Science and Engineering Technology International Conferences (ASET), pp. 1–5. IEEE Xplorer, Dubai (2019)Google Scholar
  10. 10.
    Uzun, B., Yildirim, F.S., Sayan, M., Sanlidag, T., Ozsahin, D.U.: The use of fuzzy PROMETHEE technique in antiretroviral combination decision in pediatric HIV treatments. In: Advances in Science and Engineering Technology International Conferences (ASET), pp. 1–4. IEEE Xplorer, Dubai (2019)Google Scholar
  11. 11.
    Ozsahin, D.U., Ozsahin, I.: A fuzzy PROMETHEE approach for breast cancer treatment techniques. Int. J. Med. Res. Health Sci. 7(5), 29–32 (2018)Google Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Faculty of Medicine, Clinical Laboratory, PCR UnitKocaeli UniversityKocaeliTurkey
  2. 2.Research Center of Experimental Health SciencesNear East UniversityNicosiaCyprus
  3. 3.Department of Medical MicrobiologyManisa Celal Bayar UniversityManisaTurkey
  4. 4.Department of MathematicsNear East UniversityNicosiaCyprus
  5. 5.Faculty of Medicine, Department of Medical Microbiology and Clinical MicrobiologyNear East UniversityNicosiaCyprus
  6. 6.Clinical of Infectious DiseasesHealth Science University, Antalya Educational and Research HospitalAntalyaTurkey
  7. 7.Department of Biomedical EngineeringNear East UniversityNicosiaCyprus
  8. 8.Gordon Center for Medical Imaging, Radiology DepartmentMassachusetts General Hospital and Harvard Medical SchoolBostonUSA

Personalised recommendations