Combination Therapy Using Metal Nanoparticles for Skin Infections

  • Debalina Bhattacharya
  • Rituparna Saha
  • Mainak Mukhopadhyay


Nowadays skin infections have emerged as a serious health problem worldwide. Over the years research has been conducted to develop new therapeutic agents for the treatment and prevention of various skin infections. Frequent use of conventional antibiotics and drugs increases multi-drug resistance. Therefore, it requires a continuous need for newer and more effective therapies. Nanotechnology is the most promising and novel area in the field of medicine for safe and targeted drug delivery to combat various skin infections. Nanomaterials especially metallic nanoparticles are increasingly utilized in dermatology and cosmetology due to their unique properties such as small size, shape, and high surface-area-to-volume ratio. Metallic nanoparticles have the ability to interact with the cell membrane and cell wall of the pathogens and can easily penetrate into the skin. Therefore, metal-based nanoparticles can effectively combine with conventional drugs to develop successful combination therapies. The aim of this chapter is to describe the combination therapy of metallic nanoparticles for the treatment of various skin infections.


Combination therapy Dermatology Nanomaterials Metal nanoparticles Skin infections 



Gold nanoparticles


Basal cell carcinomas


Colony-forming unit


Cutaneous leishmaniasis


Copper oxide nanoparticles


Permeability and retention effect


Epidermal parasitic skin diseases


Herpes simplex virus


Infectious diseases


Multi-drug resistance


Non-melanocytic skin cancer






Reactive oxygen species


Stratum corneum


Superparamagnetic iron oxide nanoparticles


Skin structure infections


Titanium dioxide


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Debalina Bhattacharya
    • 1
  • Rituparna Saha
    • 2
  • Mainak Mukhopadhyay
    • 2
  1. 1.Department of MicrobiologyMaulana Azad CollegeKolkataIndia
  2. 2.Department of BiotechnologyJIS UniversityKolkataIndia

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