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Nanobiotechnological Strategies for Treatment of Tegumentary and Visceral Leishmaniasis Including Resistance Strains

  • Marco Vinicius ChaudEmail author
  • Venâncio Alves Amaral
  • Fernando Batain
  • Kessi Marie Moura Crescencio
  • Carolina Alves dos Santos
  • Márcia Araújo Rebelo
  • Victória Soares Soeiro
Chapter

Abstract

Leishmaniasis is a vector-borne chronic infectious disease caused by a group of protozoan parasites of the genus Leishmania. The most severe form of the disease is visceral leishmaniasis, which is fatal if not treated properly. Leishmaniasis is one of the neglected tropical diseases caused by different species of the protozoan parasite Leishmania, and leishmaniasis is a major public health problem worldwide. Leishmania, in the amastigote development period, lives inside tissue-resident macrophages as well as migrating monocytes in distinct anatomical locations. Their hidden location is responsible for impairing the accession of drug therapy. Drug delivery systems should allow the adverse effects caused by parenteral routes of administration to be avoided as well as enhancing the antileishmanial activity and reducing the toxicity of the medication. Access to essential drugs for the treatment of leishmaniasis is challenging in the developing countries that have the highest burden of cases. In the absence of effective vector control measures, drug treatment of the host associated with the nano-theranostic vaccines is the most promising alternative against leishmaniasis. Development of vaccines against leishmaniasis does not appear to follow any specific pattern. However, it is possible to notice an effort from countries developing vaccines in recent years. Research efforts regarding the development of DNA vaccines, recombinant proteins or peptides, and adjuvants are increasing and seem to be among the best feasible alternatives for a successful vaccine. Advances in research, development, and innovation in drug delivery systems show that new dosage forms can enhance the efficacy, safety, and amenability of the old drugs including antimonials, amphotericin B, imiquimod, and buparvaquone. However, the strategy of vaccination by the cutaneous route has been an exponential development, allowing immunization against cutaneous, mucocutaneous, and visceral leishmaniasis.

Keywords

Leishmaniasis Vaccine Nanocarriers Transdermal drug delivery Neglected disease Drug resistance 

Nomenclature

AmB

Amphotericin B

Amb-d

Amphotericin B deoxycholate

AmB-UDL

Amphotericin B ultra-deformation liposome

CL

Cutaneous leishmaniasis

DALYs

Disability-adjusted life-years

DNA

Deoxyribonucleic acid

HIV

Human immunodeficiency virus

HSV-2

Herpes simplex virus type 2

IgG

Immunoglobulin G

L-AmB

Liposomal amphotericin B

MA

Meglumine antimoniate

ML

Mucocutaneous leishmaniasis

SEDDS

Self-emulsifying drug delivery systems

SNEDDS

Self-nanoemulsifying drug delivery systems

SDEDDS

Self-double-emulsifying drug delivery systems

UDL

Ultra-deformation liposome

US FDA

Food and Drug Administration

VL

Visceral leishmaniasis

WHO

World Health Organization

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Marco Vinicius Chaud
    • 1
    Email author
  • Venâncio Alves Amaral
    • 1
  • Fernando Batain
    • 1
  • Kessi Marie Moura Crescencio
    • 1
  • Carolina Alves dos Santos
    • 2
  • Márcia Araújo Rebelo
    • 3
  • Victória Soares Soeiro
    • 1
  1. 1.Laboratory of Biomaterials and NanotechnologyUniversity of SorocabaSorocabaBrazil
  2. 2.College of PharmacyUniversity of SorocabaSorocabaBrazil
  3. 3.College of PharmacyMax Planck University CenterIndaiatubaBrazil

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