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Applications of Chitosan and Nanochitosan in Formulation of Novel Antibacterial and Wound Healing Agents

  • Mehran Alavi
Chapter

Abstract

Applications of chitosan and nanochitosan biomaterials in biomedical field are based on important advantages of this biopolymer including biocompatibility, biodegradability, hemostatic, antimicrobial activities, acceleration in wound healing process, nearly controlled release of antimicrobial agents and growth factors. However, low solubility of chitosan in physiological pH condition is important disadvantage which can be resulted in fast metabolism of this biopolymer by enzymes of gastrointestinal tract. Other striking drawbacks in chitosan application are low degree of stability, mechanical resistance, and porosity which can have negative effects on wound healing. Hence, it can be used as biocomposites/nano-biocomposites forms via interaction with natural and synthetic polymers or other materials. Considering these facts, recent advancements related to wound healing and antibacterial agents based on combination of chitosan with major natural polymers involving cellulose, collagen, alginic acid, hyaluronic acid, starch, and chondroitin sulfate are presented in this chapter.

Keywords

Chitosan Nanochitosan Wound healing Antibacterial agents Natural polymer Bio-nanocomposites 

Nomenclature

AND

Andrographolide

ChNF

Chitosan nanofibril

ChNC

Chitosan nanocrystal

CN

Chitosan nanoparticle

CNC

Cellulose nanocrystal

CNF

Cellulose nanofibril

CNW

Cellulose nanowhiskers

CPP

Cell-penetrating peptide

DA

Deacetylation

ECM

Extracellular matrix

EDTAD

Ethylenediaminetetraacetic acid dianhydride

IαI

Inter-α-inhibitor

KGM

Konjac glucomannan

MRSA

Methicillin resistant Staphylococcus aureus

MSSA

Me thicillin sensitive Staphylococcus aureus

MTGase

Microbial transglutaminase

NC

Nanocellulose

NLC

Nanostructured lipid carrier

PVA

Polyvinyl alcohol

PVP

Polyvinyl pyrrolidone

S

Stearic acid

SLN

Solid lipid nanoparticle

TSG-6

TNF-stimulated gene 6

VEGF

Vascular endothelial growth factor

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Mehran Alavi
    • 1
  1. 1.Laboratory of Nanobiotechnology, Department of Biology, Faculty of ScienceRazi UniversityKermanshahIran

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