Local Field Potentials and ECoG

  • Doris D. Wang
  • Witney Chen
  • Philip A. Starr
  • Coralie de HemptinneEmail author


The ability to record human neural activity in the form of field potentials from deep brain leads or surface brain electrodes has given us immense insight into the pathophysiology of movement disorders. These recordings have shed light on the oscillatory nature of neural network and its role in normal brain physiology as well as in disease. Based on these field potential recordings, excessive synchronization of the motor network in different frequency bands may be phenomenologically associated with diverse motor symptoms of movement disorders. Similar phenomena may also be present in other neurological and psychiatric diseases, allowing novel application of stereotactic procedures to understand and treat these disorders. In this chapter, we discuss recent findings regarding the role of network oscillatory activities in movement disorders, based on studies from local field potentials and electrocorticography potentials. We also examine how this knowledge is relevant for clinical practice, both in understanding the mechanism of existing deep brain stimulation therapy as well as in refining and improving existing treatments.


Local field potentials Electrocorticography Basal ganglia Motor cortex Oscillations Movement disorders Deep brain stimulation 



Basal ganglia


Basal ganglia thalamocortical


Deep brain stimulation






Globus pallidus


Globus pallidus interna


High-frequency oscillations


Local field potentials


Primary motor cortex


Phase amplitude coupling


Parkinson’s disease


Subthalamic nucleus


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Doris D. Wang
    • 1
  • Witney Chen
    • 1
  • Philip A. Starr
    • 1
  • Coralie de Hemptinne
    • 1
    Email author
  1. 1.Department of Neurological SurgeryUniversity of California, San FranciscoSan FranciscoUSA

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