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Polymeric Nanoparticulate Delivery Vehicles of Antimicrobials for Biofilm Eradication

  • Yuezhou Zhang
  • Luofeng Yu
  • Jianhong Zhang
  • Peng LiEmail author
Chapter
  • 117 Downloads

Abstract

Given the challenge that the number of existing antibiotic resistant strains and species is increasing at an alarming rate, in particular these biofilm-associated microorganisms are often thought to be hard to eradicate by free antibiotics since they are embedded in a condensed polymeric matrix therefore hamper the effective killing. The develoment of nanotechnology enable the deeper penetration and targeting of antibiotics to noramlly unreached biofilm. Combined with the diversity of polymers, antibiotics has been formulated into different version of delivery vehicles with antimicrobials included to deplete biofilm. In addition, polymeric nanocomposite can also be assembled by incorporating other type of toxic nanoparticles to achieve synergetic biofilm eradication outcomes.

Keywords

Biofilm Eradication Polymeric nanoparticles Delivery vehicles Antimicrobials Tolerance 

Notes

Acknowledgments

This research was supported by the Fundamental Research Funds for the Central Universities of China, grant number 31020190QD030, the National Key R&D Program of China (2018YFC1105402 and 2017YFA0207202).

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Yuezhou Zhang
    • 1
  • Luofeng Yu
    • 2
  • Jianhong Zhang
    • 1
  • Peng Li
    • 1
    Email author
  1. 1.Xi’an Institute of Flexible Electronics & Xi’an Institute of Biomedical Materials and Engineering, Northwestern Polytechnical University (NPU)Xi’anChina
  2. 2.Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)Nanjing Tech University (NanjingTech)NanjingChina

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