A Nucleolar Protein, Nepro, Is Essential for the Maintenance of Early Neural Stem Cells and Preimplantation Embryos
- 5 Downloads
Notch signaling is required for maintaining neural stem cells (NSCs) in the developing brain. NSCs have potential to give rise to many neuronal types in the early telencephalon, and the potential decreases as embryonic development proceeds. Nepro, which encodes a unique nucleolar protein and is activated downstream of Notch, is essential for maintaining NSCs in the early telencephalon. Nepro is also expressed at basal levels and required for maintaining the preimplantation embryo, by repressing mitochondria-associated p53 apoptotic signaling. Notch signaling also controls dendritic complexity in mitral cells, major projection neurons in the olfactory bulb, showing that many steps of neural development involve Notch signaling.
KeywordsMib1 Maml1 Nepro Hes1 Neural stem cell Radial glia Neuron Dendrite Neocortex Telencephalon Blastocyst Morula
This work was supported by JSPS KAKENHI Grant Number 18K19369.
- Lefebvre JL, Sanes JR, Kay JN (2015) Development of dendritic form and function. Annu Rev Cell Dev Biol 31:741–777. https://doi.org/10.1146/annurev-cellbio-100913-013020CrossRefPubMedGoogle Scholar
- Lodato S, Arlotta P (2015) Generating neuronal diversity in the mammalian cerebral cortex. Annu Rev Cell Dev Biol 31:699–720. https://doi.org/10.1146/annurev-cellbio-100814–125353CrossRefPubMedPubMedCentralGoogle Scholar
- McConnell SK (1988) Fates of visual cortical neurons in the ferret after isochronic and heterochronic transplantation. J Neurosci 8:945–974. https://doi.org/10.1523/JNEUROSCI.08-03-00945.1988CrossRefPubMedPubMedCentralGoogle Scholar